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Beclomethasone 17-propionate

Name: Beclomethasone 17-propionate
Brand: TargetMol
SKU: T10494
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10494Cas No. 5534-18-9

Alias Beclomethasone-17-monopropionate, 17-BMP

Beclomethasone 17-propionate is a glucocorticoid that is the active metabolite of Beclomethasone dipropionate (BDP). As a glucocorticoid receptor (GR) agonist, 17-BMP has a 13-fold higher affinity than BDP and inhibits the production of pro-inflammatory cytokines, such as CXCL8, TNF-α, and IL-6, thus exerting an anti-inflammatory effect, and it is mainly used in the treatment of asthma and allergic rhinitis.

Beclomethasone 17-propionate

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Purity: 98.06%

Catalog No. T10494Alias Beclomethasone-17-monopropionate, 17-BMPCas No. 5534-18-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$64	-	In Stock
10 mg	$98	-	In Stock
25 mg	$183	-	In Stock
50 mg	$297	-	In Stock
100 mg	$446	-	In Stock
200 mg	$645	-	In Stock
1 mL x 10 mM (in DMSO)	$66	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.06%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Beclomethasone 17-propionate is a glucocorticoid that is the active metabolite of Beclomethasone dipropionate (BDP). As a glucocorticoid receptor (GR) agonist, 17-BMP has a 13-fold higher affinity than BDP and inhibits the production of pro-inflammatory cytokines, such as CXCL8, TNF-α, and IL-6, thus exerting an anti-inflammatory effect, and it is mainly used in the treatment of asthma and allergic rhinitis.
In vitro	Beclomethasone 17-propionate has EC50 values of 0.05 nM, 0.01 nM, and 0.1 nM for IL-6, TNFα, and CXCL8, respectively. [3]
Synonyms	Beclomethasone-17-monopropionate, 17-BMP

Chemical Properties

Molecular Weight	464.98
Formula	C₂₅H₃₃ClO₆
Cas No.	5534-18-9
Smiles	O(C(CC)=O)[C@@]1(C(CO)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](Cl)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (215.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1506 mL	10.7532 mL	21.5063 mL	107.5315 mL
5 mM	0.4301 mL	2.1506 mL	4.3013 mL	21.5063 mL
10 mM	0.2151 mL	1.0753 mL	2.1506 mL	10.7532 mL
20 mM	0.1075 mL	0.5377 mL	1.0753 mL	5.3766 mL
50 mM	0.0430 mL	0.2151 mL	0.4301 mL	2.1506 mL
100 mM	0.0215 mL	0.1075 mL	0.2151 mL	1.0753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc