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Beclomethasone 17-propionate

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Catalog No. T10494Cas No. 5534-18-9
Alias Beclomethasone-17-monopropionate, 17-BMP

Beclomethasone 17-propionate is a glucocorticoid that is the active metabolite of Beclomethasone dipropionate (BDP). As a glucocorticoid receptor (GR) agonist, 17-BMP has a 13-fold higher affinity than BDP and inhibits the production of pro-inflammatory cytokines, such as CXCL8, TNF-α, and IL-6, thus exerting an anti-inflammatory effect, and it is mainly used in the treatment of asthma and allergic rhinitis.

Beclomethasone 17-propionate
Other Forms of Beclomethasone 17-propionate:

Beclomethasone 17-propionate

🥰Excellent
Purity: 98.06%
Catalog No. T10494Alias Beclomethasone-17-monopropionate, 17-BMPCas No. 5534-18-9
Beclomethasone 17-propionate is a glucocorticoid that is the active metabolite of Beclomethasone dipropionate (BDP). As a glucocorticoid receptor (GR) agonist, 17-BMP has a 13-fold higher affinity than BDP and inhibits the production of pro-inflammatory cytokines, such as CXCL8, TNF-α, and IL-6, thus exerting an anti-inflammatory effect, and it is mainly used in the treatment of asthma and allergic rhinitis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30-In Stock
5 mg$64-In Stock
10 mg$98-In Stock
25 mg$183-In Stock
50 mg$297-In Stock
100 mg$446-In Stock
200 mg$645-In Stock
1 mL x 10 mM (in DMSO)$66-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.06%
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Product Introduction

Bioactivity
Description
Beclomethasone 17-propionate is a glucocorticoid that is the active metabolite of Beclomethasone dipropionate (BDP). As a glucocorticoid receptor (GR) agonist, 17-BMP has a 13-fold higher affinity than BDP and inhibits the production of pro-inflammatory cytokines, such as CXCL8, TNF-α, and IL-6, thus exerting an anti-inflammatory effect, and it is mainly used in the treatment of asthma and allergic rhinitis.
In vitro
Beclomethasone 17-propionate has EC50 values ​​of 0.05 nM, 0.01 nM, and 0.1 nM for IL-6, TNFα, and CXCL8, respectively. [3]
SynonymsBeclomethasone-17-monopropionate, 17-BMP
Chemical Properties
Molecular Weight464.98
FormulaC25H33ClO6
Cas No.5534-18-9
SmilesO(C(CC)=O)[C@@]1(C(CO)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](Cl)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]
Relative Density.1.30 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (215.06 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1506 mL10.7532 mL21.5063 mL107.5315 mL
5 mM0.4301 mL2.1506 mL4.3013 mL21.5063 mL
10 mM0.2151 mL1.0753 mL2.1506 mL10.7532 mL
20 mM0.1075 mL0.5377 mL1.0753 mL5.3766 mL
50 mM0.0430 mL0.2151 mL0.4301 mL2.1506 mL
100 mM0.0215 mL0.1075 mL0.2151 mL1.0753 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

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