Shopping Cart
Remove All
Your shopping cart is currently empty
δ-secretase inhibitor 11
Copy Product Info
🥰Excellent
Catalog No. T9713Cas No. 842964-18-5
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
δ-secretase inhibitor 11
Copy Product Info🥰Excellent
Purity: 99.84%
Catalog No. T9713Cas No. 842964-18-5
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $30 | In Stock | In Stock | |
| 10 mg | $43 | In Stock | In Stock | |
| 25 mg | $97 | In Stock | In Stock | |
| 50 mg | $167 | In Stock | - | |
| 100 mg | $249 | In Stock | - | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.84%
Appearance:Solid
Color:Red
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment. |
| Targets&IC50 | Caspase-8:86.71 ± 10 μM, Caspase-3:31.86 ± 1. μM |
| In vitro | The inhibitory effect of δ-secretase inhibitor 11 on AEP activity in vitro was tested and the dose-response relationship revealed that the δ-secretase inhibitor 11 had an IC50 value of 0.15 ± 0.09 μM [1]. |
| In vivo | It was found that oral administration of δ-secretase inhibitor 11 (10 mg/kg) significantly suppressed brain AEP activity compared to the vehicle treatment. The concentrations of Aβ1–40 and Aβ1–42 in brain lysates of SAMP8 mice were significantly reduced due to AEP inhibition by δ-secretase inhibitor 11. [1] |
| Molecular Weight | 220.23 |
| Formula | C10H12N4O2 |
| Cas No. | 842964-18-5 |
| Smiles | Nc1ccc(N2CCOCC2)c2nonc12 |
| Relative Density. | 1.390 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.21 mg/mL (10.03 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
δ-Secretase inhibitor 11δsecretase inhibitor 11δ secretase inhibitor 11β-amyloid peptideβAmyloidβ AmyloidPala cellsoxygen-glucose deprivationInhibitorinhibitdelta-secretase inhibitor 11CNS diseasesCaspaseBetaAmyloidBeta AmyloidbAmyloidb Amyloidasparagine endopeptidaseAPPamyloid-βamyloid precursor proteinAlzheimer's diseaseAEPAbeta
Preview
Related Tags: buy δ-secretase inhibitor 11 | purchase δ-secretase inhibitor 11 | δ-secretase inhibitor 11 cost | order δ-secretase inhibitor 11 | δ-secretase inhibitor 11 chemical structure | δ-secretase inhibitor 11 in vivo | δ-secretase inhibitor 11 in vitro | δ-secretase inhibitor 11 formula | δ-secretase inhibitor 11 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.