Calcimycin hemicalcium salt

Name: Calcimycin hemicalcium salt
Brand: TargetMol
SKU: T10662
Rating: 4.5 (1 reviews)

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Catalog No. T10662Cas No. 59450-89-4

Alias Antibiotic A-23187 hemicalcium salt, A-23187 hemicalcium salt

Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration.

Calcimycin hemicalcium salt

😃Good

Catalog No. T10662Alias Antibiotic A-23187 hemicalcium salt, A-23187 hemicalcium saltCas No. 59450-89-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration.
In vitro	Calcimycin hemicalcium salt mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner [4].
In vivo	Calcimycin hemicalcium salt (2.5 or 7.5 nM; intrapleural) induces protein leakage [5].
Synonyms	Antibiotic A-23187 hemicalcium salt, A-23187 hemicalcium salt

Chemical Properties

Molecular Weight	1085.322
Formula	C₅₈H₇₂CaN₆O₁₂
Cas No.	59450-89-4
Smiles	CNc1ccc2OC3=[N]4c2c1C(=O)[O-][Ca++]412([O-]C(=O)c4c5c(OC(CC6OC7(CCC6C)OC(C(C)CC7C)C(C)C(=[O]1)c1ccc[nH]1)=[N]25)ccc4NC)[O]=C(C(C)C1OC2(CCC(C)C(C3)O2)C(C)CC1C)c1ccc[nH]1 \|w:53.62,41.46,c:7,t:53,^1:8,47\|
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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