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KYN-101

Name: KYN-101
Brand: TargetMol
SKU: T72056
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T72056Cas No. 2247950-73-6

Alias KYN101, KYN 101

KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity. KYN-101 decreases CYP1A1 mRNA expression and can be used in the study of breast cancer and acute myeloid leukemia. KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.

KYN-101

🥰Excellent

Purity: 98.35%

Catalog No. T72056Alias KYN101, KYN 101Cas No. 2247950-73-6

Pack Size	Price	Availability
1 mg	$61	In Stock
5 mg	$147	In Stock
10 mg	$228	In Stock
25 mg	$428	In Stock
50 mg	$662	In Stock
100 mg	$993	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.35%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity. KYN-101 decreases CYP1A1 mRNA expression and can be used in the study of breast cancer and acute myeloid leukemia. KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.
In vivo	KYN-101 (10 mg/kg; once daily for 12 days; oral administration) treatment in 6-8-week-old C57BL/6J mice (B16IDO tumor-bearing mice) significantly reduced tumor growth. Additionally, the combination of KYN-101 and anti-PD-1 antibody further delayed tumor growth and extended survival in CT26 models[1].
Synonyms	KYN101, KYN 101

Chemical Properties

Molecular Weight	386.43
Formula	C₂₂H₁₉FN₆
Cas No.	2247950-73-6
Smiles	FC1=CN=CC(=C1)C2=NC3=C(C=NN3C(=C2)NCCC4=CNC=5C=CC=CC54)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (207.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5878 mL	12.9390 mL	25.8779 mL	129.3895 mL
5 mM	0.5176 mL	2.5878 mL	5.1756 mL	25.8779 mL
10 mM	0.2588 mL	1.2939 mL	2.5878 mL	12.9390 mL
20 mM	0.1294 mL	0.6469 mL	1.2939 mL	6.4695 mL
50 mM	0.0518 mL	0.2588 mL	0.5176 mL	2.5878 mL
100 mM	0.0259 mL	0.1294 mL	0.2588 mL	1.2939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc