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CGS 21680

Catalog No. T6441L CAS 120225-54-9

CGS 21680 is a chemical compound that acts as a selective agonist for both adenosine and its A2A receptor, demonstrating a binding affinity (K i) of 27 nM.

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CGS 21680, CAS 120225-54-9

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,520.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CGS 21680 is a chemical compound that acts as a selective agonist for both adenosine and its A2A receptor, demonstrating a binding affinity (K i) of 27 nM.
In vitro	CGS21680 notably increases the levels of CD39 and CD73 expression and enhances the breakdown of adenosine triphosphate (ATP) into adenosine [1]. While CGS21680 at a concentration of 10 nM demonstrates minimal survival activity independently, this activity is substantially boosted when combined with the phosphodiesterase inhibitor, IBMX. The enhancement of motoneuron survival by CGS21680 is attributed to the combined influence of the adenylate cyclase-cAMP-PKA pathway and the transactivation of neurotrophin receptors [4].
In vivo	CGS21680 (1 mg/kg/i.p.) administration enhances the progression of experimental autoimmune neuritis (EAN) in bovine peripheral myelin-induced Lewis rats by worsening the condition. This aggravation involves a decrease in CD4+ Foxp3+ T cells and an increase in CD4+ CXCR5+ T cells, B cells, dendritic cells, and antigen-specific autoantibodies, likely due to CGS21680's suppression of IL-2. At a lower dose (0.1 mg/kg, i.p.), CGS21680 temporarily raises heart rate without affecting blood pressure in rats, and at an even lower dose (0.01 mg/kg), it has no impact on heart rate or blood pressure. Post-transient middle cerebral artery occlusion (MCAo), CGS21680, at both dosages, offers protection against neurological deficits for up to 7 days, reduces microgliosis and astrogliosis, and enhances myelin organization in the striatum as well as the cytoarchitecture of the ischemic cortex and striatum. Additionally, two days post-transient MCAo, it diminishes the number of infiltrated granulocytes in ischemic tissue.

Molecular Weight	499.52
Formula	C23H29N7O6
CAS No.	120225-54-9

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

CGS 21680 120225-54-9 CGS-21680 CGS21680 inhibitor inhibit

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