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ent-Prostaglandin E2

Name: ent-Prostaglandin E2
Brand: TargetMol
SKU: T35991
Rating: 4.5 (1 reviews)

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Catalog No. T35991Cas No. 65085-69-0

Alias ent-Prostaglandin E2

Enzymatically-derived prostaglandin E2 (PGE2) is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of PGE2. Significant amounts of racemic PGE2 (rac-PGE2) are generated in vitro and in vivo in settings of oxidative stress via the isoprostane pathway. A proposed mechanism for the formation of rac-PGE2 involves the base catalyzed equilibration from 15-E2t-isoprostane (8-iso-PGE2), generated from the 15-H2t-isoprostane endoperoxide.

ent-Prostaglandin E2

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Catalog No. T35991Alias ent-Prostaglandin E2Cas No. 65085-69-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 μg	$159	35 days	35 days
500 μg	$282	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Synonyms

ent-Prostaglandin E2

Chemical Properties

Molecular Weight	352.471
Formula	C₂₀H₃₂O₅
Cas No.	65085-69-0
Smiles	CCCCC[C@@H](O)\C=C\[C@@H]1[C@@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 2 mg/mL (5.67 mM), Sonication is recommended.

DMF: 50 mg/mL (141.86 mM), Sonication is recommended.

Ethanol: 50 mg/mL (141.86 mM), Sonication is recommended.

DMSO: 50 mg/mL (141.86 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8371 mL	14.1856 mL	28.3711 mL	141.8556 mL
5 mM	0.5674 mL	2.8371 mL	5.6742 mL	28.3711 mL

DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2837 mL	1.4186 mL	2.8371 mL	14.1856 mL
20 mM	0.1419 mL	0.7093 mL	1.4186 mL	7.0928 mL
50 mM	0.0567 mL	0.2837 mL	0.5674 mL	2.8371 mL
100 mM	0.0284 mL	0.1419 mL	0.2837 mL	1.4186 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc