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NKL 22

Name: NKL 22
Brand: TargetMol
SKU: T3206
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3206Cas No. 537034-15-4

Alias PAOA, Histone Deacetylase Inhibitor IV

NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.

NKL 22

🥰Excellent

Purity: 96.24%

Catalog No. T3206Alias PAOA, Histone Deacetylase Inhibitor IVCas No. 537034-15-4

NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.

Pack Size	Price	Availability
10 mg	$29	In Stock
25 mg	$58	In Stock
50 mg	$94	In Stock
100 mg	$148	In Stock
200 mg	$219	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:96.24%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.
Targets&IC50	HDAC8:5 μM (IC50), HDAC3:0.069 μM (IC50), HDAC1:0.199 μM (IC50), HDAC2:1.59 μM (IC50)
Synonyms	PAOA, Histone Deacetylase Inhibitor IV

Chemical Properties

Molecular Weight	325.4
Formula	C₁₉H₂₃N₃O₂
Cas No.	537034-15-4
Smiles	Nc1ccccc1NC(=O)CCCCCC(=O)Nc1ccccc1
Relative Density.	1.213g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (153.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0731 mL	15.3657 mL	30.7314 mL	153.6570 mL
5 mM	0.6146 mL	3.0731 mL	6.1463 mL	30.7314 mL
10 mM	0.3073 mL	1.5366 mL	3.0731 mL	15.3657 mL
20 mM	0.1537 mL	0.7683 mL	1.5366 mL	7.6829 mL
50 mM	0.0615 mL	0.3073 mL	0.6146 mL	3.0731 mL
100 mM	0.0307 mL	0.1537 mL	0.3073 mL	1.5366 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc