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NKL 22

Name: NKL 22
Brand: TargetMol
SKU: T3206
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3206Cas No. 537034-15-4

Alias PAOA, Histone Deacetylase Inhibitor IV

NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.

NKL 22

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Purity: 96.24%

Catalog No. T3206Alias PAOA, Histone Deacetylase Inhibitor IVCas No. 537034-15-4

NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$29	In Stock	In Stock
25 mg	$58	In Stock	In Stock
50 mg	$94	In Stock	In Stock
100 mg	$148	In Stock	In Stock
200 mg	$219	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:96.24%

Color:White

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COA HNMR LCMS

Product Introduction

NKL 22 AI Summary

NKL 22 exhibits significant bioactivity as a histone deacetylase (HDAC) inhibitor, particularly potent against HDAC1 and HDAC3/NCOR2 with IC50 values of 199.0 nM and 69.0 nM, respectively. It also shows moderate activity against HDAC2 (IC50 = 1590.0 nM) and HDAC8 (IC50 = 5000.0 nM), but negligible activity against HDAC4, HDAC5, HDAC7, and HDAC8 (IC50 > 180,000.0 nM). In U937 cells, NKL 22 inhibits HDAC1 by 28.9% at 5 µM without affecting HDAC4 and induces granulocytic differentiation as evidenced by an 18.3% increase in CD11c expression after 30 hours at the same concentration. Additionally, the compound enhances FXN mRNA expression and frataxin protein levels in lymphocytes from Friedreich's ataxia patients and exhibits inhibition of HDACs in HeLa cell extracts. For its antiviral properties, NKL 22 inhibits SARS-CoV-2 3CL-Pro protease by 9.33% at 20 µM and demonstrates modest antiviral activity by reducing SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM with an inhibition rate of 0.26%. Furthermore, NKL 22 shows cytotoxic activity against human HepG2 cells with an IC50 of 11700.0 nM, indicating its potential as a cytotoxic agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.
Targets&IC50	HDAC8:5 μM (IC50), HDAC1:0.199 μM (IC50), HDAC3:0.069 μM (IC50), HDAC2:1.59 μM (IC50)
Synonyms	PAOA, Histone Deacetylase Inhibitor IV

Chemical Properties

Molecular Weight	325.4
Formula	C₁₉H₂₃N₃O₂
Cas No.	537034-15-4
Smiles	Nc1ccccc1NC(=O)CCCCCC(=O)Nc1ccccc1
Relative Density.	1.213g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (153.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0731 mL	15.3657 mL	30.7314 mL	153.6570 mL
5 mM	0.6146 mL	3.0731 mL	6.1463 mL	30.7314 mL
10 mM	0.3073 mL	1.5366 mL	3.0731 mL	15.3657 mL
20 mM	0.1537 mL	0.7683 mL	1.5366 mL	7.6829 mL
50 mM	0.0615 mL	0.3073 mL	0.6146 mL	3.0731 mL
100 mM	0.0307 mL	0.1537 mL	0.3073 mL	1.5366 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc