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CC-90003

Name: CC-90003
Brand: TargetMol
SKU: T14894
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14894Cas No. 1621999-82-3

CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.

CC-90003

🥰Excellent

Purity: 99.42%

Catalog No. T14894Cas No. 1621999-82-3

CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.

Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$81	In Stock
10 mg	$139	In Stock
25 mg	$278	In Stock
50 mg	$396	In Stock
100 mg	$591	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.42%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.
In vitro	CC-90003 is an irreversible and selective ERK 1/2 inhibitor with antitumor activity [1].

Chemical Properties

Molecular Weight	458.44
Formula	C₂₂H₂₁F₃N₆O₂
Cas No.	1621999-82-3
Smiles	COc1cc(Nc2ncc(c(Nc3ccc(C)cc3NC(=O)C=C)n2)C(F)(F)F)c(C)cn1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (272.66 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1813 mL	10.9066 mL	21.8131 mL	109.0655 mL
5 mM	0.4363 mL	2.1813 mL	4.3626 mL	21.8131 mL
10 mM	0.2181 mL	1.0907 mL	2.1813 mL	10.9066 mL
20 mM	0.1091 mL	0.5453 mL	1.0907 mL	5.4533 mL
50 mM	0.0436 mL	0.2181 mL	0.4363 mL	2.1813 mL
100 mM	0.0218 mL	0.1091 mL	0.2181 mL	1.0907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc