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Synucleozid

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Catalog No. T13049Cas No. 502139-01-7
Alias NSC 377363

Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson's disease.

Synucleozid
Other Forms of Synucleozid:
Synucleozid hydrochlorideT13049L2741856-68-6
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Synucleozid

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Catalog No. T13049Alias NSC 377363Cas No. 502139-01-7
Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson's disease.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson's disease.
Targets&IC50
SNCA IRE RNA:1.5 μM
In vitro
Synucleozid (0.25-1 μM; 24 hours) eliminates α-synuclein preformed fibrils induced cytotoxicity by acting as seeds and recruiting endogenous α-synuclein aggregation. It binds to the A bulge near the base of the IRE hairpin, reducing α-synuclein levels in a dose-dependent manner (IC50: 500 nM), and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells. Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities, decreasing 2-AP emission (EC50: 2.7 μM), with recovery observed as a function of unlabeled SNCA IRE RNA concentration, yielding a competitive Kd of 1.5 μM. Additionally, Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins with IREs in their mRNA's UTR, such as APP, PrP, Ferritin, and TfR, in a dose-dependent manner. All panels are completed in SH-SY5Y cells, except for PrP protein, which is assessed in Neuro-2A cells.
SynonymsNSC 377363
Chemical Properties
Molecular Weight368.43
FormulaC22H20N6
Cas No.502139-01-7
SmilesC(=N)(N)C=1C=C2C(C=C(N2)C3=CC=C(NC4=CC=C(C(=N)N)C=C4)C=C3)=CC1
Relative Density.1.36 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
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Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
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Keywords

SynucleozidSNCA IRE RNANSC-377363NSC377363
Related Tags: buy Synucleozid | purchase Synucleozid | Synucleozid cost | order Synucleozid | Synucleozid chemical structure | Synucleozid in vitro | Synucleozid formula | Synucleozid molecular weight
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