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Anti-RON/CD136 Antibody-PE (9E783)
🥰Excellent
Catalog No. TMAY-01925P
Anti-RON/CD136 Antibody-PE (9E783) is a PE-conjugated Mouse antibody targeting RON/CD136. Anti-RON/CD136 Antibody-PE (9E783) can be used in FCM.
Anti-RON/CD136 Antibody-PE (9E783)
Anti-RON/CD136 Antibody-PE (9E783)
🥰Excellent
Catalog No. TMAY-01925P
Anti-RON/CD136 Antibody-PE (9E783) is a PE-conjugated Mouse antibody targeting RON/CD136. Anti-RON/CD136 Antibody-PE (9E783) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-RON/CD136 Antibody-PE (9E783) is a PE-conjugated Mouse antibody targeting RON/CD136. Anti-RON/CD136 Antibody-PE (9E783) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 9E783 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD136 expression on SW480 cells. Cells were stained with PE-conjugated anti-Human CD136. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD136/MST1R (rh CD136/MST1R; TMPY-02028; Q04912; Met1-Leu571) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury and points to strategies for intervention in the progression of inflammatory diseases. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis. Stimulation of MST1R leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphatidylinositol (PI)3-kinase pathway, and the JNK pathway. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human CD136/MST1R Protein (TMPY-02028) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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