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AR 231453

Name: AR 231453
Brand: TargetMol
SKU: T8329
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8329Cas No. 733750-99-7

Azenosertib (ZN-c3) is an orally active, specific GPR119 agonist. Azenosertib (ZN-c3) stimulates cell proliferation and improves pancreatic β-cell function. [1]

AR 231453

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Purity: 99.34%

Catalog No. T8329Cas No. 733750-99-7

Azenosertib (ZN-c3) is an orally active, specific GPR119 agonist. Azenosertib (ZN-c3) stimulates cell proliferation and improves pancreatic β-cell function. [1]

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$63	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$228	In Stock	In Stock
100 mg	$355	-	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.34%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Azenosertib (ZN-c3) is an orally active, specific GPR119 agonist. Azenosertib (ZN-c3) stimulates cell proliferation and improves pancreatic β-cell function. [1]

Chemical Properties

Molecular Weight	505.52
Formula	C₂₁H₂₄FN₇O₅S
Cas No.	733750-99-7
Smiles	N(=O)(=O)C=1C(=NC=NC1NC2=C(F)C=C(S(C)(=O)=O)C=C2)N3CCC(CC3)C4=NC(C(C)C)=NO4
Relative Density.	1.421 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (19.78 mM), Sonication is recommended.

H2O: 60 mg/mL (118.69 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9782 mL	9.8908 mL	19.7816 mL	98.9081 mL
5 mM	0.3956 mL	1.9782 mL	3.9563 mL	19.7816 mL
10 mM	0.1978 mL	0.9891 mL	1.9782 mL	9.8908 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0989 mL	0.4945 mL	0.9891 mL	4.9454 mL
50 mM	0.0396 mL	0.1978 mL	0.3956 mL	1.9782 mL
100 mM	0.0198 mL	0.0989 mL	0.1978 mL	0.9891 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc