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TGFβRI-IN-3

Name: TGFβRI-IN-3
Brand: TargetMol
SKU: T9523
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9523Cas No. 2763602-67-9

TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology [1].

TGFβRI-IN-3

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Purity: 99.85%

Catalog No. T9523Cas No. 2763602-67-9

TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology [1].

Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$197	In Stock
10 mg	$313	In Stock
25 mg	$613	In Stock
50 mg	$955	In Stock
100 mg	$1,370	In Stock
500 mg	$2,730	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock

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Purity:99.85%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology [1].
In vitro	TGFβRI-IN-3 inhibits TGFβR1 at an IC 50 of 0.79 nM, 2000-fold selectivity for MAP4K4 [1].

Chemical Properties

Molecular Weight	465.57
Formula	C₂₈H₂₃N₃O₂S
Cas No.	2763602-67-9
Smiles	N(C=1C2=C(C=C(C=C2)C3=CC=C(S(C)(=O)=O)C=C3)N=CC1)C=4C=C(N=CC4)C5=CC(C)=CC=C5
Relative Density.	1.276 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.40 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1479 mL	10.7395 mL	21.4790 mL	107.3952 mL
5 mM	0.4296 mL	2.1479 mL	4.2958 mL	21.4790 mL
10 mM	0.2148 mL	1.0740 mL	2.1479 mL	10.7395 mL
20 mM	0.1074 mL	0.5370 mL	1.0740 mL	5.3698 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1479 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc