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Immuno modulator-1

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Catalog No. T79170Cas No. 2757469-20-6

Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 nM and 26 nM, respectively, and exhibits a 20% inhibitory effect on the hERG potassium channel at a concentration of 3 μM [1].

Immuno modulator-1

Immuno modulator-1

😃Good
Catalog No. T79170Cas No. 2757469-20-6
Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 nM and 26 nM, respectively, and exhibits a 20% inhibitory effect on the hERG potassium channel at a concentration of 3 μM [1].
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5 mgInquiry8-10 weeks
50 mgInquiry8-10 weeks
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Product Introduction

Bioactivity
Description
Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 nM and 26 nM, respectively, and exhibits a 20% inhibitory effect on the hERG potassium channel at a concentration of 3 μM [1].
In vitro
Immune modulator-1 (compound 22) inhibits the proliferation of NCI-H929 human myeloma cells with an IC50 of 0.6 nM [1].
In vivo
Immuno modulator-1 (compound 22) administered at 1 mg/kg IV and 5 mg/kg PO demonstrated 30% oral bioavailability in male Sprague-Dawley rats [1].
Chemical Properties
Molecular Weight582.62
FormulaC32H31FN6O4
Cas No.2757469-20-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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