Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC) with IC50 values of 4.7 nM and 26 nM, respectively. Additionally, this compound exhibits a 20% inhibitory effect on the hERG potassium channel at a concentration of 3 μM [1].
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Description | Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC) with IC50 values of 4.7 nM and 26 nM, respectively. Additionally, this compound exhibits a 20% inhibitory effect on the hERG potassium channel at a concentration of 3 μM [1]. |
In vitro | Immune modulator-1 (compound 22) inhibits the proliferation of NCI-H929 human myeloma cells with an IC50 of 0.6 nM [1]. |
In vivo | Immuno modulator-1 (compound 22) administered at a dosage of 1 mg/kg intravenously (IV) and 5 mg/kg orally (PO) demonstrated an oral bioavailability of 30% in male Sprague-Dawley rats [1]. |
Molecular Weight | 582.62 |
Formula | C32H31FN6O4 |
CAS No. | 2757469-20-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Immuno modulator-1 2757469-20-6 inhibitor inhibit