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NCT-501

Name: NCT-501
Brand: TargetMol
SKU: T6903
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6903Cas No. 1802088-50-1

Alias NCT501

NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with an IC50 of 40 nM.

NCT-501

🥰Excellent

Purity: 99.19%

Catalog No. T6903Alias NCT501Cas No. 1802088-50-1

NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with an IC50 of 40 nM.

Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$97	In Stock
10 mg	$167	In Stock
25 mg	$343	In Stock
50 mg	$529	In Stock
100 mg	$767	In Stock

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Batch Information

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Purity:99.19%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with an IC50 of 40 nM.
Targets&IC50	ALDH1A1:40 nM
In vitro	In Caco-2 cell line, NCT-501 exhibits excellent permeability. [1]
In vivo	In CD1 Mice, NCT-501 is well absorbed and distributed but rapidly metabolized and/or excreted. [1]
Synonyms	NCT501

Chemical Properties

Molecular Weight	416.52
Formula	C₂₁H₃₂N₆O₃
Cas No.	1802088-50-1
Smiles	CC(C)CCn1c(CN2CCN(CC2)C(=O)C2CC2)nc2n(C)c(=O)n(C)c(=O)c12
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1.04 mg/mL (2.5 mM), Sonication is recommended.

Ethanol: 24 mg/mL (57.62 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.4008 mL	12.0042 mL	24.0085 mL	120.0423 mL

Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.4802 mL	2.4008 mL	4.8017 mL	24.0085 mL
10 mM	0.2401 mL	1.2004 mL	2.4008 mL	12.0042 mL
20 mM	0.1200 mL	0.6002 mL	1.2004 mL	6.0021 mL
50 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4008 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc