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HDAC1/MAO-B-IN-1

Catalog No. T60947 CAS 2759855-37-1

HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-B-IN-1 for HDAC1 and MAO-B are 21.4 nM and 99.0 nM, respectively [1].

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HDAC1/MAO-B-IN-1, CAS 2759855-37-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-B-IN-1 for HDAC1 and MAO-B are 21.4 nM and 99.0 nM, respectively [1].
In vitro	HDAC1/MAO-B-IN-1 (compound 1f) demonstrates inhibitory effects on hMAO-B, hMAO-A, and hHDAC1 with IC50 values of 99.0 nM, 9923.0 nM, and 21.4 nM, respectively [1]. Additionally, at a concentration of 50 μM over 24 hours, it exhibits neuroprotective effects and suppresses reactive oxygen species (ROS) production in PC12 cells, as confirmed by a Cell Viability Assay [1].
In vivo	Administered intragastrically (i.g.) at 20 mg/kg, HDAC1/MAO-B-IN-1 demonstrates favorable permeability across the blood-brain barrier (BBB) [1]. When administered intraperitoneally (i.p.) at 15 mg/kg for 15 consecutive days, it enhances the learning and memory functionalities in ICR mice, both male (6-8 weeks old) and female (20-25 g) models [1].

Molecular Weight	328.79
Formula	C18H17ClN2O2
CAS No.	2759855-37-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HDAC1/MAO-B-IN-1 2759855-37-1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.