Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 233.00 | |
5 mg | 5 days | $ 297.00 | |
25 mg | 6-8 weeks | $ 916.00 | |
50 mg | 6-8 weeks | $ 1,190.00 | |
100 mg | 6-8 weeks | $ 1,860.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 318.00 |
Description | RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1]. |
In vitro | RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range[1]. |
Molecular Weight | 391.46 |
Formula | C23H25N3O3 |
CAS No. | 2351843-48-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (319.32 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. More
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RAS inhibitor Abd-7 2351843-48-4 RAS inhibitor Abd7 RAS inhibitor Abd 7 inhibitor inhibit