Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is typically 0.1-1 ng/mL.

NRG1 beta 1 Protein, Human, Recombinant (aa 176-246) is expressed in E. coli. The accession number is Q02297-6.

Human

E. coli

SMDF,NRG1-IT2,NDF,MSTP131,MST131,HRGA,HRG1,HRG,HGL,Heregulin beta-1,GGF2,GGF,ARIA

A DNA sequence encoding the Human NRG1 (Q02297-6) (Thr176-Lys246) was expressed with an N-terminal Met.

≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.

Please refer to the lot-specific COA.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.