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Tenovin-6

Name: Tenovin-6
Brand: TargetMol
SKU: T1818
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1818Cas No. 1011557-82-6

Alias Tenovin 6

Tenovin-6 is a p53 transcriptional activity agonist.

Tenovin-6

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Purity: 98.89%

Catalog No. T1818Alias Tenovin 6Cas No. 1011557-82-6

Tenovin-6 is a p53 transcriptional activity agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
2 mg	$51	In Stock	In Stock
5 mg	$70	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$159	In Stock	In Stock
50 mg	$243	In Stock	In Stock
100 mg	$413	In Stock	In Stock
500 mg	$979	-	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.89%

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tenovin-6 is a p53 transcriptional activity agonist.
Targets&IC50	SIRT2:10 μM, SIRT1:21 μM, SIRT3:67 μM
In vivo	Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1].
Kinase Assay	Assays are carried out using purified components in the Fluor de Lys Fluorescent Assay Systems. Relevant FdL substrates are used at 7 μM and NAD+ at 1 mM. Tenovins are solubilized in DMSO with the final DSMO concentration in the reaction being less than 0.25%. For SirT1 and HDAC8, one unit of enzyme is used per reaction, and for SirT2 and SirT3, five units is used per reaction. Reactions are carried out at 37°C for 1 hr.
Cell Research	The MTS assay is used to evaluate cell viability. UM cells are seeded into each well of 96-well plates (5,000 cells/well) and treated the next day with control or Tenovin-6 in an increasing concentrations from 0 to 20?μM for 68?h, and then MTS is added at 20?μL/well to be read at a wave length of 490?nm, the IC50 is determined by curve fitting of the sigmoidal dose-response curve.
Synonyms	Tenovin 6

Chemical Properties

Molecular Weight	454.63
Formula	C₂₅H₃₄N₄O₂S
Cas No.	1011557-82-6
Smiles	CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
Relative Density.	1.171 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 91 mg/mL (200.16 mM), Sonication is recommended.

H2O: 90 mg/mL (197.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1996 mL	10.9980 mL	21.9959 mL	109.9795 mL
5 mM	0.4399 mL	2.1996 mL	4.3992 mL	21.9959 mL
10 mM	0.2200 mL	1.0998 mL	2.1996 mL	10.9980 mL
20 mM	0.1100 mL	0.5499 mL	1.0998 mL	5.4990 mL
50 mM	0.0440 mL	0.2200 mL	0.4399 mL	2.1996 mL
100 mM	0.0220 mL	0.1100 mL	0.2200 mL	1.0998 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc