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Arecaidine
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Catalog No. TN1398Cas No. 499-04-7
Arecaidine is an alkaloid naturally present in areca nuts that functions as a γ-aminobutyric acid (GABA) reuptake inhibitor, displaying structural similarity to other GABA uptake inhibitors and demonstrating sedative effects in murine models, as well as protective activity against lethality induced by GABAA receptor antagonists, thereby supporting its use in neuropharmacological and inhibitory neurotransmission research.
Arecaidine
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Purity: 99.76%
Catalog No. TN1398Cas No. 499-04-7
Arecaidine is an alkaloid naturally present in areca nuts that functions as a γ-aminobutyric acid (GABA) reuptake inhibitor, displaying structural similarity to other GABA uptake inhibitors and demonstrating sedative effects in murine models, as well as protective activity against lethality induced by GABAA receptor antagonists, thereby supporting its use in neuropharmacological and inhibitory neurotransmission research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $32 | - | In Stock | |
| 5 mg | $73 | - | In Stock | |
| 10 mg | $123 | - | In Stock | |
| 25 mg | $198 | - | In Stock | |
| 50 mg | $297 | - | In Stock | |
| 100 mg | $453 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.76%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Arecaidine is an alkaloid naturally present in areca nuts that functions as a γ-aminobutyric acid (GABA) reuptake inhibitor, displaying structural similarity to other GABA uptake inhibitors and demonstrating sedative effects in murine models, as well as protective activity against lethality induced by GABAA receptor antagonists, thereby supporting its use in neuropharmacological and inhibitory neurotransmission research. |
| In vivo | Method: Arecaidine and guvacine were tested in vitro using cat spinal cord and cerebellar slices and administered intravenously, topically, or subcutaneously in cats and mice at doses up to 1 g/kg. Result: Arecaidine and guvacine inhibited GABA uptake and enhanced GABAergic inhibition in vitro, but showed minimal anticonvulsant or synaptic inhibitory effects in vivo[1]. |
| Molecular Weight | 141.17 |
| Formula | C7H11NO2 |
| Cas No. | 499-04-7 |
| Smiles | O=C(O)C1=CCCN(C)C1 |
| Relative Density. | 1.166g/cm3 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 200 mg/mL (1416.73 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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