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NF-κB-IN-15

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Catalog No. T209424

NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. It reduces NO levels in LPS-stimulated cells and suppresses the release of IL-6, TNF-α, and IL-1β. Additionally, it hinders LPS-induced p65 phosphorylation and IκBα degradation. NF-κB-IN-15 exhibits anti-inflammatory properties and holds potential for research in acute lung injury (ALI).

NF-κB-IN-15

NF-κB-IN-15

😃Good
Catalog No. T209424
NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. It reduces NO levels in LPS-stimulated cells and suppresses the release of IL-6, TNF-α, and IL-1β. Additionally, it hinders LPS-induced p65 phosphorylation and IκBα degradation. NF-κB-IN-15 exhibits anti-inflammatory properties and holds potential for research in acute lung injury (ALI).
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Bioactivity
Description
NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. It reduces NO levels in LPS-stimulated cells and suppresses the release of IL-6, TNF-α, and IL-1β. Additionally, it hinders LPS-induced p65 phosphorylation and IκBα degradation. NF-κB-IN-15 exhibits anti-inflammatory properties and holds potential for research in acute lung injury (ALI).
In vitro
NF-κB-IN-15 (compound 14r) reduces NO levels in a dose-dependent manner and inhibits IL-6, TNF-α, and IL-1β in LPS-induced RAW 264.7 cells when applied at concentrations of 1.25, 2.5, 5, 10, and 20 µM for 1+24 hours. Additionally, NF-κB-IN-15 at 10 and 20 µM for 1+4 hours suppresses LPS-induced p65 phosphorylation and IκBα degradation.
In vivo
NF-κB-IN-15 (compound 14r) (20 mg/kg; i.p.) demonstrates anti-inflammatory effects in mice with acute lung injury (ALI).
Chemical Properties
FormulaC46H58N4O8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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