Shopping Cart

Your shopping cart is currently empty

TTBK1-IN-1

Name: TTBK1-IN-1
Brand: TargetMol
SKU: T40348
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T40348Cas No. 2735015-60-6

Alias TTBK1-IN-1

TTBK1-IN-1 (compound 31) is a potent and selective tau microtubule protein kinase 1 (TTBK1) inhibitor (IC50=315 nM) with central nervous system (CNS) penetration that inhibits tau phosphorylation at the disease-associated Ser 422 epitope, and can be used to study Alzheimer's disease.

TTBK1-IN-1

Copy Product Info

😃Good

Catalog No. T40348Alias TTBK1-IN-1Cas No. 2735015-60-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$129	-	In Stock
2 mg	$189	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	TTBK1-IN-1 (compound 31) is a potent and selective tau microtubule protein kinase 1 (TTBK1) inhibitor (IC50=315 nM) with central nervous system (CNS) penetration that inhibits tau phosphorylation at the disease-associated Ser 422 epitope, and can be used to study Alzheimer's disease.
In vitro	In primary mouse neurons at DIV14, short-term treatment (1 hour) with TTBK1-IN-1 at concentrations from 0.0625 to 100 μM had no effect on neurite length. However, longer exposures (6-24 hours) at the same concentration range led to a significant reduction in neurite length starting around 12-18 hours after treatment[1].
In vivo	In mice, intraperitoneal injection of TTBK1-IN-1 (2.5-180 mg/kg, given 5 min before isoflurane exposure) significantly reduced tau phosphorylation at Ser422 in the brain at 180 mg/kg. A dose-dependent trend was also observed: 20 mg/kg reduced p-Ser422 levels by 21%, while 60 mg/kg led to a 60% reduction, in a model of isoflurane-induced hypothermia[1].
Synonyms	TTBK1-IN-1

Chemical Properties

Molecular Weight	337.38
Formula	C₁₈H₁₉N₅O₂
Cas No.	2735015-60-6
Smiles	C(#C[C@@](CC)(C)O)C=1C=C2N(C=CC2=CN1)C=3C=C(OC)N=C(N)N3

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20 mg/mL (59.28 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9640 mL	14.8201 mL	29.6402 mL	148.2008 mL
5 mM	0.5928 mL	2.9640 mL	5.9280 mL	29.6402 mL
10 mM	0.2964 mL	1.4820 mL	2.9640 mL	14.8201 mL
20 mM	0.1482 mL	0.7410 mL	1.4820 mL	7.4100 mL
50 mM	0.0593 mL	0.2964 mL	0.5928 mL	2.9640 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc