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TTBK1-IN-1

Catalog No. T40348 CAS 2735015-60-6

Synonyms: TTBK1-IN-1

TTBK1-IN-1 is a highly potent and selective inhibitor of tau tubulin kinase 1 (TTBK1), capable of penetrating the blood-brain barrier with ease. With an IC 50 value of 2.7 nM, TTBK1-IN-1 exhibits strong inhibitory activity against TTBK1. This compound holds great promise for advancing research in Alzheimer's disease and other tauopathies.

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TTBK1-IN-1, CAS 2735015-60-6

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	TTBK1-IN-1 is a highly potent and selective inhibitor of tau tubulin kinase 1 (TTBK1), capable of penetrating the blood-brain barrier with ease. With an IC 50 value of 2.7 nM, TTBK1-IN-1 exhibits strong inhibitory activity against TTBK1. This compound holds great promise for advancing research in Alzheimer's disease and other tauopathies.
In vitro	In primary mouse neuronal cultures at 14 days in vitro (DIV14), where analyses of neurite branching serve as indicators of neuronal health, the chemical compound TTBK1-IN-1 was evaluated for its effects on neurite length. Acute exposure (up to 1 hour after administration) of TTBK1-IN-1, in concentrations ranging from 0.0625 to 100 μM, did not alter neurite length. However, during chronic exposure tests, where TTBK1-IN-1 was administered at the same concentration range for durations of 6 to 24 hours, a significant reduction in neurite length was observed at concentrations of 50 and 100 μM, with these effects manifesting between 12 to 18 hours post-treatment[1].
In vivo	TTBK1-IN-1 (intraperitoneal injection; doses of 2.5, 7, 20, 60, and 180 mg/kg administered 5 minutes prior to isoflurane treatment) significantly reduces tau phosphorylation at disease-relevant sites in vivo, particularly at the 180 mg/kg dosage. Additionally, a dose-dependent reduction in tau phosphorylation levels at Ser 422 was observed, with a 21% decrease at 20 mg/kg and a 60% decrease at 60 mg/kg, compared to the vehicle-treated control, in a mouse model of isoflurane-induced hypothermia[1].

Synonyms	TTBK1-IN-1
Molecular Weight	337.383
Formula	C18H19N5O2
CAS No.	2735015-60-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tamara Halkina, et al. Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem. 2021 May 13;64(9):6358-6380.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TTBK1-IN-1 2735015-60-6 TTBK1 IN 1 TTBK1IN1 TTBK-1-IN-1 inhibitor inhibit

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