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Hexahydrocurcumin
🥰Excellent
Catalog No. TQ0288Cas No. 36062-05-2
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
Hexahydrocurcumin
🥰Excellent
Purity: 99.88%
Catalog No. TQ0288Cas No. 36062-05-2
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $81 | In Stock | In Stock | |
| 5 mg | $198 | In Stock | In Stock | |
| 10 mg | $328 | In Stock | In Stock | |
| 25 mg | $662 | In Stock | In Stock | |
| 50 mg | $987 | In Stock | In Stock | |
| 100 mg | $1,390 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $327 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.88%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. |
| In vitro | Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) significantly decreased HT-29 colon cancer cell viability in a time- and concentration-dependent manner, with IC50 values of 77.05 μM at 24 hours and 56.95 μM at 48 hours. When combined with 5-fluorouracil (5-FU; 5 μM), Hexahydrocurcumin markedly reduced COX-2 expression without altering COX-1 levels [1]. Moreover, Hexahydrocurcumin (7-14 μM; 24 hours) attenuated LPS-induced prostaglandin E2 (PGE2) increase in murine macrophages (RAW 264.7) in a concentration-dependent manner [2]. |
| In vivo | In colon cancer rats, Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci. Hexahydrocurcumin also markedly decreases COX-2 protein expression [3]. |
| Cell Research | Cell Line: HT-29 cells. Concentration: 0 μM, 5 μM, 10 μM, 25 μM. Incubation Time: 24 hours or 48 hours [1] |
| Animal Research | Animal Model: Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH). Dosage: 50 mg/kg. Administration: Oral administration; daily; for 16 weeks [3] |
| Molecular Weight | 374.43 |
| Formula | C21H26O6 |
| Cas No. | 36062-05-2 |
| Smiles | COc1cc(CCC(O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O |
| Relative Density. | 1.226 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (120.18 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.34 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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