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GLP-1R Antagonist 1

Name: GLP-1R Antagonist 1
Brand: TargetMol
SKU: T15387
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15387Cas No. 488097-06-9

GLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).

GLP-1R Antagonist 1

😃Good

Purity: 99.84%

Catalog No. T15387Cas No. 488097-06-9

GLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	-
5 mg	$89	Inquiry	Inquiry
10 mg	$147	Inquiry	Inquiry
25 mg	$287	Inquiry	Inquiry
50 mg	$455	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$97	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).
Targets&IC50	GLP1 receptor:650 nM

Chemical Properties

Molecular Weight	440.73
Formula	C₁₆H₁₁ClF₆N₄O₂
Cas No.	488097-06-9
Smiles	Cn1c2NC(=NC(c2c(=O)n(C)c1=O)(C(F)(F)F)C(F)(F)F)c1ccc(Cl)cc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (204.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.49 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2690 mL	11.3448 mL	22.6896 mL	113.4481 mL
5 mM	0.4538 mL	2.2690 mL	4.5379 mL	22.6896 mL
10 mM	0.2269 mL	1.1345 mL	2.2690 mL	11.3448 mL
20 mM	0.1134 mL	0.5672 mL	1.1345 mL	5.6724 mL
50 mM	0.0454 mL	0.2269 mL	0.4538 mL	2.2690 mL
100 mM	0.0227 mL	0.1134 mL	0.2269 mL	1.1345 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc