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ZINC00784494

Name: ZINC00784494
Brand: TargetMol
SKU: T78149
Rating: 4.5 (1 reviews)

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Catalog No. T78149Cas No. 317328-17-9

Alias ZINC 00784494

ZINC00784494 is a selective inhibitor of LCN2 (lipocalin-2), which inhibits cancer cell proliferation and reduces AKT phosphorylation levels, prevents the transition of the cell cycle from the G0/G1 phase to the S phase, and promotes apoptosis. It can be used for the study of inflammatory breast cancer (IBC).

ZINC00784494

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Purity: 98.90%

Catalog No. T78149Alias ZINC 00784494Cas No. 317328-17-9

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Purity:98.90%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ZINC00784494 is a selective inhibitor of LCN2 (lipocalin-2), which inhibits cancer cell proliferation and reduces AKT phosphorylation levels, prevents the transition of the cell cycle from the G0/G1 phase to the S phase, and promotes apoptosis. It can be used for the study of inflammatory breast cancer (IBC).
In vitro	Method: Cell viability assay was performed to evaluate the effect of ZINC00784494 on SUM149 cells. Cells were exposed to various concentrations of ZINC00784494 (0.01 to 100 µM) and incubated for 72 hours. Result: ZINC00784494 significantly reduced the viability of SUM149 cells at concentrations of 1 µM or lower. [1]
Alias	ZINC 00784494

Chemical Properties

Molecular Weight	362.4
Formula	C₂₀H₁₄N₂O₃S
Cas No.	317328-17-9
Smiles	O=C1OC=2C=CC=CC2C=C1C=3N=C(SC3)NC4=CC=CC(=C4)C(=O)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (220.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7594 mL	13.7969 mL	27.5938 mL	137.9691 mL
5 mM	0.5519 mL	2.7594 mL	5.5188 mL	27.5938 mL
10 mM	0.2759 mL	1.3797 mL	2.7594 mL	13.7969 mL
20 mM	0.1380 mL	0.6898 mL	1.3797 mL	6.8985 mL
50 mM	0.0552 mL	0.2759 mL	0.5519 mL	2.7594 mL
100 mM	0.0276 mL	0.1380 mL	0.2759 mL	1.3797 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc