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Anti-APPL1 Antibody (2A728)

😃Good
Catalog No. TMAB-02786

Anti-APPL1 Antibody (2A728) is a Rabbit antibody targeting APPL1. Anti-APPL1 Antibody (2A728) can be used in WB,IHC-P,IHC-Fr,IF.

Anti-APPL1 Antibody (2A728)

Anti-APPL1 Antibody (2A728)

😃Good
Catalog No. TMAB-02786
Anti-APPL1 Antibody (2A728) is a Rabbit antibody targeting APPL1. Anti-APPL1 Antibody (2A728) can be used in WB,IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1497-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-APPL1 Antibody (2A728) is a Rabbit antibody targeting APPL1. Anti-APPL1 Antibody (2A728) can be used in WB,IHC-P,IHC-Fr,IF.
Clone
2A728
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationEarly endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Tissue SpecificityHigh levels in heart, ovary, pancreas and skeletal muscle.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
A synthesized peptide: human Dip13 alpha
Gene Name
APPL1
Gene ID
Protein Name
DCC-interacting protein 13-alpha
Function
Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Chemical Properties
Molecular WeightTheoretical: 80 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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