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SNT-207858 free base

Name: SNT-207858 free base
Brand: TargetMol
SKU: T12945
Rating: 4.5 (1 reviews)

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Catalog No. T12945Cas No. 1104662-66-9

SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).

SNT-207858 free base

😃Good

Catalog No. T12945Cas No. 1104662-66-9

Pack Size	Price	Availability
5 mg	$446	6-8 weeks
25 mg	$1,430	6-8 weeks
50 mg	$1,860	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).
In vitro	SNT207858 exhibits binding affinity to the MC-4 receptor at 22 nM, demonstrating significant selectivity with a 170-fold preference compared to MC-3 and a 40-fold preference over MC-5.
In vivo	In mice,the tumor induced weight loss significantly reduced by SNT207858 (30 mg/kg; oral administration; once daily; 15 days).

Chemical Properties

Molecular Weight	616.62
Formula	C₃₂H₄₃Cl₂N₅O₃
Cas No.	1104662-66-9
Relative Density.	1.258 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (202.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6217 mL	8.1087 mL	16.2174 mL	81.0872 mL
5 mM	0.3243 mL	1.6217 mL	3.2435 mL	16.2174 mL
10 mM	0.1622 mL	0.8109 mL	1.6217 mL	8.1087 mL
20 mM	0.0811 mL	0.4054 mL	0.8109 mL	4.0544 mL
50 mM	0.0324 mL	0.1622 mL	0.3243 mL	1.6217 mL
100 mM	0.0162 mL	0.0811 mL	0.1622 mL	0.8109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc