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Fosfenopril

Name: Fosfenopril
Brand: TargetMol
SKU: T20518
Price: 90 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20518Cas No. 95399-71-6

Alias SQ27519, SQ 27519, Fosinoprilic acid, Fosinoprilat

Fosfenopril (Fosinoprilat) is a potent angiotensin-converting enzyme (ACE) inhibitor that mitigates lipopolysaccharide-induced inflammation in monocytes through the suppression of TLR4/NF-κB signaling pathways, and Fosfenopril is utilized in cardiovascular and anti-inflammatory research to investigate molecular mechanisms of ACE inhibition.

Fosfenopril

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Purity: 99.05%

Catalog No. T20518Alias SQ27519, SQ 27519, Fosinoprilic acid, FosinoprilatCas No. 95399-71-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$90	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.05%

Color:White

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COA MS HPLC

Product Introduction

Bioactivity

Description	Fosfenopril (Fosinoprilat) is a potent angiotensin-converting enzyme (ACE) inhibitor that mitigates lipopolysaccharide-induced inflammation in monocytes through the suppression of TLR4/NF-κB signaling pathways, and Fosfenopril is utilized in cardiovascular and anti-inflammatory research to investigate molecular mechanisms of ACE inhibition.
In vitro	Fosfenopril (0-10 μM) treatment for 5 minutes can inhibit the LPS-induced increase in TLR4 expression [1]. Fosfenopril (0-10 μM) treatment for 1 hour can reduce the LPS-activated NF-κB expression level [1]. Fosfenopril also inhibits the expression of LPS-induced pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) [1].
In vivo	Single intravenous injection of Fosfenopril (0.5 mg/kg bolus plus 0.1 mg/kg/min) can increase para-aminohippuric acid (PAH) clearance and glomerular filtration rate (GFR) in canines [3].
Synonyms	SQ27519, SQ 27519, Fosinoprilic acid, Fosinoprilat

Chemical Properties

Molecular Weight	435.49
Formula	C₂₃H₃₄NO₅P
Cas No.	95399-71-6
Smiles	C(CP(CCCCC1=CC=CC=C1)(=O)O)(=O)N2C[C@@H](C[C@H]2C(O)=O)C3CCCCC3
Relative Density.	1.238g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (183.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2963 mL	11.4813 mL	22.9626 mL	114.8132 mL
5 mM	0.4593 mL	2.2963 mL	4.5925 mL	22.9626 mL
10 mM	0.2296 mL	1.1481 mL	2.2963 mL	11.4813 mL
20 mM	0.1148 mL	0.5741 mL	1.1481 mL	5.7407 mL
50 mM	0.0459 mL	0.2296 mL	0.4593 mL	2.2963 mL
100 mM	0.0230 mL	0.1148 mL	0.2296 mL	1.1481 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc