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Fosfenopril

Name: Fosfenopril
Brand: TargetMol
SKU: T20518
Price: 138 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20518Cas No. 95399-71-6

Alias SQ27519, SQ 27519, Fosinoprilic acid, Fosinoprilat

Fosfenopril (Fosinoprilat) is a potent angiotensin-converting enzyme (ACE) inhibitor that mitigates lipopolysaccharide-induced inflammation in monocytes through the suppression of TLR4/NF-κB signaling pathways, and Fosfenopril is utilized in cardiovascular and anti-inflammatory research to investigate molecular mechanisms of ACE inhibition.

Fosfenopril

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Catalog No. T20518Alias SQ27519, SQ 27519, Fosinoprilic acid, FosinoprilatCas No. 95399-71-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$138	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Fosfenopril (Fosinoprilat) is a potent angiotensin-converting enzyme (ACE) inhibitor that mitigates lipopolysaccharide-induced inflammation in monocytes through the suppression of TLR4/NF-κB signaling pathways, and Fosfenopril is utilized in cardiovascular and anti-inflammatory research to investigate molecular mechanisms of ACE inhibition.
In vitro	Fosfenopril (0-10 μM) treatment for 5 minutes can inhibit the LPS-induced increase in TLR4 expression [1]. Fosfenopril (0-10 μM) treatment for 1 hour can reduce the LPS-activated NF-κB expression level [1]. Fosfenopril also inhibits the expression of LPS-induced pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) [1].
In vivo	Single intravenous injection of Fosfenopril (0.5 mg/kg bolus plus 0.1 mg/kg/min) can increase para-aminohippuric acid (PAH) clearance and glomerular filtration rate (GFR) in canines [3].
Synonyms	SQ27519, SQ 27519, Fosinoprilic acid, Fosinoprilat

Chemical Properties

Molecular Weight	435.49
Formula	C₂₃H₃₄NO₅P
Cas No.	95399-71-6
Smiles	C(CP(CCCCC1=CC=CC=C1)(=O)O)(=O)N2C[C@@H](C[C@H]2C(O)=O)C3CCCCC3
Relative Density.	1.238g/cm3
Color	White
Appearance	Lyophilized powder

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (183.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.58 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2963 mL	11.4813 mL	22.9626 mL	114.8132 mL
5 mM	0.4593 mL	2.2963 mL	4.5925 mL	22.9626 mL
10 mM	0.2296 mL	1.1481 mL	2.2963 mL	11.4813 mL
20 mM	0.1148 mL	0.5741 mL	1.1481 mL	5.7407 mL
50 mM	0.0459 mL	0.2296 mL	0.4593 mL	2.2963 mL
100 mM	0.0230 mL	0.1148 mL	0.2296 mL	1.1481 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc