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BI-671800

Name: BI-671800
Brand: TargetMol
SKU: T14565
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14565Cas No. 1093108-50-9

Alias Cmpd A, AP-761

BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2].

BI-671800

🥰Excellent

Purity: 99.19%

Catalog No. T14565Alias Cmpd A, AP-761Cas No. 1093108-50-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$108	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$326	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$629	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$122	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.19%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2].
Targets&IC50	CRTH2 (mouse):3.7 nM (in CRTH2 transfected cells), CRTH2 (human):4.5 nM (in CRTH2 transfected cells)
In vitro	BI-671800 (compound A) is a potent small-molecule antagonist with low nanomolar potency against human or mouse CRTH2 in transfected cells[1].
In vivo	BI-671800 (compound A, 0.1-10 mg/kg, i.g.) significantly inhibits AHR in mice[1] and effectively prevents edema formation, reduces inflammatory infiltrate, and alleviates skin pathology observed in drug vehicle-treated animals[3].
Synonyms	Cmpd A, AP-761

Chemical Properties

Molecular Weight	501.5
Formula	C₂₅H₂₆F₃N₅O₃
Cas No.	1093108-50-9
Smiles	CN(C)c1nc(Cc2ccc(NC(=O)c3ccc(cc3)C(F)(F)F)cc2)nc(N(C)C)c1CC(O)=O
Relative Density.	1.351 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (259.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9940 mL	9.9701 mL	19.9402 mL	99.7009 mL
5 mM	0.3988 mL	1.9940 mL	3.9880 mL	19.9402 mL
10 mM	0.1994 mL	0.9970 mL	1.9940 mL	9.9701 mL
20 mM	0.0997 mL	0.4985 mL	0.9970 mL	4.9850 mL
50 mM	0.0399 mL	0.1994 mL	0.3988 mL	1.9940 mL
100 mM	0.0199 mL	0.0997 mL	0.1994 mL	0.9970 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc