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Anti-CAV1 Antibody (2M160) (Synonyms: Caveolin-1, CAV 1, CAV)
Catalog No. TMAH-00146 Copy Product Info
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Anti-CAV1 Antibody (2M160) is an antibody targeting CAV1. Anti-CAV1 Antibody (2M160) can be used in ELISA,FCM,WB.
Anti-CAV1 Antibody (2M160)
Copy Product Info🥰Excellent
Catalog No. TMAH-00146
Synonyms Caveolin-1, CAV 1, CAV
Anti-CAV1 Antibody (2M160) is an antibody targeting CAV1. Anti-CAV1 Antibody (2M160) can be used in ELISA,FCM,WB.
Anti-CAV1 Antibody
(2M160)
(2M160)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-CAV1 Antibody (2M160) is an antibody targeting CAV1. Anti-CAV1 Antibody (2M160) can be used in ELISA,FCM,WB. |
| Synonyms | Caveolin-1, CAV 1, CAV |
| Ig Type | Rabbit IgG |
| Clone | 2M160 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: THP-1 whole cell lysate -All lanes: Caveolin-1 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 20 kDa -Observed band size: 20 kDa 2. Overlay Peak curve showing Hela cells stained with TMAH-00146 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | |
| Recommended Dose | WB:1:500-1:2000; FCM:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. |
| Tissue Specificity | Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human CAV1 |
| Antigen Species | Human |
| Gene Name | CAV1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Tags & Cell Markers, Metabolism, Signal transduction |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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