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UK 088800

Name: UK 088800
Brand: TargetMol
SKU: T7715
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7715Cas No. 139756-21-1

UK 088800 is a bioacitve chemical

UK 088800

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Purity: 99.54%

Catalog No. T7715Cas No. 139756-21-1

UK 088800 is a bioacitve chemical

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$30	-	In Stock
1 g	$35	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.54%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

UK 088800 AI Summary

UK 088800 exhibits potent inhibitory activity on various phosphodiesterase (PDE) enzymes, specifically showing IC50 values of 790.0 nM for PDE1 from rat liver, 27.0 nM for PDE5 from human corpus cavernosum, and 27.0 nM for PDE5 from rabbit platelets. In addition, it demonstrates an IC50 of 40.0 nM for PDE5 and shows minimal activity against PDE3 and PDE4 with IC50 values greater than 500.0 nM. The compound also features a lipophilicity profile indicated by a LogD value of 4.0. These properties suggest that UK 088800 has significant therapeutic potential in conditions where PDE inhibition is beneficial. Furthermore, it has diverse bioactivities in assays targeting various enzymes and conditions, including Cruzain, ALDH1A1, Menin-MLL interaction in leukemias, HPGD, G9a, ELG1-dependent DNA repair, ClpP activation, and HCV inhibition, although with less potency in these areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	UK 088800 is a bioacitve chemical
Targets&IC50	PDE1:300 nM, PDE5:5 nM

Chemical Properties

Molecular Weight	312.37
Formula	C₁₇H₂₀N₄O₂
Cas No.	139756-21-1
Smiles	CCCc1nn(C)c2c1nc([nH]c2=O)-c1ccccc1OCC
Relative Density.	1.26g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (32.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1 mg/mL (3.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2013 mL	16.0067 mL	32.0133 mL	160.0666 mL
5 mM	0.6403 mL	3.2013 mL	6.4027 mL	32.0133 mL
10 mM	0.3201 mL	1.6007 mL	3.2013 mL	16.0067 mL
20 mM	0.1601 mL	0.8003 mL	1.6007 mL	8.0033 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc