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Ramoplanin is an antibiotic extracted from Actinoplanes spp., a topical lipoglycopeptide antibacterial agent that inhibits gram-positive bacteria by binding to a critical lipid II intermediate, preventing peptidoglycan formation in the cell wall.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $45 | In Stock | |
5 mg | $79 | In Stock | |
10 mg | $112 | In Stock |
Description | Ramoplanin is an antibiotic extracted from Actinoplanes spp., a topical lipoglycopeptide antibacterial agent that inhibits gram-positive bacteria by binding to a critical lipid II intermediate, preventing peptidoglycan formation in the cell wall. |
In vitro | Ramoplanin is a glycoliptide antibiotic with activity against gram-positive bacteria. The MIC of Ramoplanin against susceptible gram-positive cocci was < = 2.0 μg/mL.[1] |
In vivo | A mouse model treated with Ramoplanin (100 μg/mL) in drinking water for 8 days was found to effectively inhibit the ability of Vancomycin-resistant Enterococcus (VRE) to colonize the intestines of mice. [2] |
Cas No. | 76168-82-6 |
Relative Density. | no data available |
Sequence | Met-Thr-Pro-Phe-Trp-Arg-Gly-Val-Ser-Leu-Arg-Pro-Ile-Gly-Ala-Ser-Cys-Arg-Asp-Asp-Ser-Glu-Cys-Ile-Thr-Arg-Leu-Cys-Arg-Lys-Arg-Arg-Cys-Ser-Leu-Ser-Val-Ala-Gln-Glu (Disulfide bridge:Cys17-Cys28;Cys23-Cys33) |
Sequence Short | MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE (Disulfide bridge:Cys17-Cys28;Cys23-Cys33) |
Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Solubility Information | DMSO: 30 mg/mL, Sonication is recommended. |
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