AGN 194078

Name: AGN 194078
Brand: TargetMol
SKU: T10265
Rating: 4.5 (1 reviews)

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Catalog No. T10265Cas No. 321995-62-4

AGN 194078 is a selective RARα agonist with a dissociation constant (Kd) of 3 nM and an effective concentration (EC50) of 112 nM.

AGN 194078

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Catalog No. T10265Cas No. 321995-62-4

AGN 194078 is a selective RARα agonist with a dissociation constant (Kd) of 3 nM and an effective concentration (EC50) of 112 nM.

Pack Size	Price	Availability
25 mg	$1,520	8-10 weeks
50 mg	$1,980	8-10 weeks
100 mg	$2,500	8-10 weeks

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	AGN 194078 is a selective RARα agonist with a dissociation constant (Kd) of 3 nM and an effective concentration (EC50) of 112 nM.
Targets&IC50	RARα:3 nM （Kd), RARα:112 nM （EC50）
In vitro	AGN 194078 binds to RARα with very high affinity (Kd: 3 nM), while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activated RARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested.

Chemical Properties

Molecular Weight	403.42
Formula	C₂₂H₂₃F₂NO₄
Cas No.	321995-62-4
Relative Density.	1.295 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

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