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idalopirdine

Name: idalopirdine
Brand: TargetMol
SKU: T7103
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7103Cas No. 467459-31-0

Alias Lu AE58054

Idalopirdine (Lu AE58054), a selective 5-HT6 receptor antagonist( Ki : 0.83 nM),as a treatment for Alzheimer's disease.

idalopirdine

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Purity: 99.73%

Catalog No. T7103Alias Lu AE58054Cas No. 467459-31-0

Idalopirdine (Lu AE58054), a selective 5-HT6 receptor antagonist( Ki : 0.83 nM),as a treatment for Alzheimer's disease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
2 mg	$121	In Stock	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$267	In Stock	In Stock
25 mg	$451	In Stock	In Stock
50 mg	$663	In Stock	In Stock
100 mg	$945	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.73%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

idalopirdine AI Summary

idalopirdine exhibits potent bioactivity as an antagonist at the 5-HT6 receptor, showing a high binding affinity with a Ki value of 0.83 nM. In addition to its activity on 5-HT6, it shows moderate affinity at the 5-HT2A receptor (Ki of 791.0 nM) and low affinity at the 5-HT1A (Ki of 3936.0 nM) and 5-HT7 receptors (Ki of 8635.0 nM), as well as the D2 receptor (Ki of 1215.0 nM). Furthermore, idalopirdine has demonstrated antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM. The compound also shows rapid intrinsic clearance and a short half-life in rat liver microsomes, indicating high metabolic stability. These properties suggest that idalopirdine has significant potential in modulating serotonin receptor activity and antiviral applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Idalopirdine (Lu AE58054), a selective 5-HT6 receptor antagonist( Ki : 0.83 nM),as a treatment for Alzheimer's disease.
Targets&IC50	5-HT6:0.83 nM(Ki)
Synonyms	Lu AE58054

Chemical Properties

Molecular Weight	398.37
Formula	C₂₀H₁₉F₅N₂O
Cas No.	467459-31-0
Smiles	C(CNCC1=CC(OCC(C(F)F)(F)F)=CC=C1)C=2C=3C(NC2)=CC(F)=CC3
Relative Density.	1.309 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (138.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5102 mL	12.5511 mL	25.1023 mL	125.5115 mL
5 mM	0.5020 mL	2.5102 mL	5.0205 mL	25.1023 mL
10 mM	0.2510 mL	1.2551 mL	2.5102 mL	12.5511 mL
20 mM	0.1255 mL	0.6276 mL	1.2551 mL	6.2756 mL
50 mM	0.0502 mL	0.2510 mL	0.5020 mL	2.5102 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2551 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc