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K-Ras G12C-IN-2

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Catalog No. T11736Cas No. 1629267-75-9

K-Ras G12C-IN-2 is a covalent KRAS G12C inhibitor.

K-Ras G12C-IN-2

K-Ras G12C-IN-2

😃Good
Catalog No. T11736Cas No. 1629267-75-9
K-Ras G12C-IN-2 is a covalent KRAS G12C inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,8208-10 weeks8-10 weeks
50 mg$2,3808-10 weeks8-10 weeks
100 mg$3,1008-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
K-Ras G12C-IN-2 is a covalent KRAS G12C inhibitor.
Chemical Properties
Molecular Weight418.92
FormulaC21H27ClN4O3
Cas No.1629267-75-9
Relative Density.1.393 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 22 mg/mL (52.52 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3871 mL11.9355 mL23.8709 mL119.3545 mL
5 mM0.4774 mL2.3871 mL4.7742 mL23.8709 mL
10 mM0.2387 mL1.1935 mL2.3871 mL11.9355 mL
20 mM0.1194 mL0.5968 mL1.1935 mL5.9677 mL
50 mM0.0477 mL0.2387 mL0.4774 mL2.3871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

K-Ras G12C-IN-2K-Ras G-12C-IN-2KRas G12CIN2KRas G12CK Ras G12C IN 2
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