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Molindone hydrochloride

Name: Molindone hydrochloride
Brand: TargetMol
SKU: T0716
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0716Cas No. 15622-65-8

Alias EN-1733A

Molindone hydrochloride (EN-1733A) is an indole derivative effective in treating schizophrenia and other psychoses by blocking dopamine's effects in the brain.

Molindone hydrochloride

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Purity: 99.99%

Catalog No. T0716Alias EN-1733ACas No. 15622-65-8

Molindone hydrochloride (EN-1733A) is an indole derivative effective in treating schizophrenia and other psychoses by blocking dopamine's effects in the brain.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$42	In Stock	In Stock
50 mg	$60	In Stock	In Stock
100 mg	$80	In Stock	In Stock
500 mg	$188	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Appearance:Solid

Color:White

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Product Introduction

Molindone hydrochloride AI Summary

Molindone hydrochloride exhibits a diverse range of bioactivities, including notable potency in inhibiting the proliferation of Plasmodium falciparum lines (Dd2 and W2), modulation of Lamin A splicing, and inhibition of Bloom's syndrome helicase (BLM). It also acts as an antagonist to the Acetylcholine Muscarinic M1 receptor and demonstrates both inhibitory and activator activity towards Cytochrome P450 3A4. Additionally, Molindone hydrochloride shows inhibitory effects against Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) and has been found to impede the binding or entry of Marburg Virus and Ebola Virus into cells. In assays measuring cell viability in Vero E6 cells infected with SARS-CoV-2, the compound exhibits an inhibition index of 0.4807, indicating lower activity compared to the control (arbidol). In terms of antimicrobial properties, Molindone hydrochloride shows weak antifungal activity against Candida albicans and Cryptococcus neoformans and displays varying antibacterial activities against Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, but negligible or negative effects on Klebsiella pneumoniae and Staphylococcus aureus MRSA..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Molindone hydrochloride (EN-1733A) is an indole derivative effective in treating schizophrenia and other psychoses by blocking dopamine's effects in the brain.
Synonyms	EN-1733A

Chemical Properties

Molecular Weight	312.84
Formula	C₁₆H₂₄N₂O₂·HCl
Cas No.	15622-65-8
Smiles	Cl.CCc1c(C)[nH]c2CCC(CN3CCOCC3)C(=O)c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (159.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1965 mL	15.9826 mL	31.9652 mL	159.8261 mL
5 mM	0.6393 mL	3.1965 mL	6.3930 mL	31.9652 mL
10 mM	0.3197 mL	1.5983 mL	3.1965 mL	15.9826 mL
20 mM	0.1598 mL	0.7991 mL	1.5983 mL	7.9913 mL
50 mM	0.0639 mL	0.3197 mL	0.6393 mL	3.1965 mL
100 mM	0.0320 mL	0.1598 mL	0.3197 mL	1.5983 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc