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Crizanlizumab
(Synonyms: SEG-101, ADAKVEO) Copy Product Info
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Synonyms: SEG-101, ADAKVEO
Catalog No. T77399 Copy Product Info
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Crizanlizumab (Adakveo) is a humanized monoclonal antibody against P-selectin for the prevention of pain crises in sickle cell disease.
Cas No. 1690318-25-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $239 | - | In Stock | |
| 5 mg | $787 | - | In Stock | |
| 10 mg | $1,320 | - | In Stock | |
| 25 mg | $1,960 | - | In Stock | |
| 50 mg | $2,650 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 95%
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Antibody Information
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| Description | Crizanlizumab (Adakveo) is a humanized monoclonal antibody against P-selectin for the prevention of pain crises in sickle cell disease. |
| In vivo | 'Crizanlizumab (1 or 6 mg/kg; intraperitoneal injection; three times a week; for 5 months) improves sickle cell retinopathy in 4-week-old male HbSS (sickle cell disease) mice[2].' |
| Endotoxin | <1.0 EU/mg |
| Synonyms | SEG-101, ADAKVEO |
| Reactivity | Human |
| Verified Activity | Immobilized Human P-Selectin Protein (His) (TMPY-02709) at 1 μg/mL (100 μL/well) can bind Crizanlizumab. The EC50 is 3.18 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | P-Selectin/CD62p |
| Molecular Weight | 150 kDa |
| Cas No. | 1690318-25-2 |
| Isotype | Human IgG2 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Crizanlizumab chemical structure | Crizanlizumab in vivo | Crizanlizumab molecular weight
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