Anti-LGR-5 Polyclonal Antibody

Name: Anti-LGR-5 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01063
Rating: 4.5 (1 reviews)

(Synonyms: LGR5, HG38, G-protein coupled receptor HG38, G-protein coupled receptor 67, G-protein coupled receptor 49, GPR67, GPR49) Copy Product Info

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Synonyms: LGR5, HG38, G-protein coupled receptor HG38, G-protein coupled receptor 67, G-protein coupled receptor 49, GPR67, GPR49

Catalog No. TMAB-01063 Copy Product Info

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Anti-LGR-5 Polyclonal Antibody is a Rabbit antibody targeting LGR-5. Anti-LGR-5 Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P, WB.

Anti-LGR-5 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$528	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-LGR-5 Polyclonal Antibody is a Rabbit antibody targeting LGR-5. Anti-LGR-5 Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P, WB.
Synonyms	LGR5, HG38, G-protein coupled receptor HG38, G-protein coupled receptor 67, G-protein coupled receptor 49, GPR67, GPR49
Ig Type	IgG
Reactivity	Human,Mouse (predicted:Rat)

Application	FCM IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of th
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Antigen Details

Immunogen	KLH conjugated synthetic peptide: mouse GPR49
Antigen Species	Mouse
Gene Name	LGR5
Gene ID	14160
Protein Name	Leucine-rich repeat-containing G-protein coupled receptor 5
Uniprot ID	Q9Z1P4
Biology Area	GPCR,GPCR,Surface Molecules
Function	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.