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S1PR1 modulator 1

Name: S1PR1 modulator 1
Brand: TargetMol
SKU: T12821
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12821Cas No. 2328109-05-1

S1PR1 modulator 1 is a selective inhibitor of S1PR1, with a pIC50 of 7.6.

S1PR1 modulator 1

🥰Excellent

Purity: 99.69%

Catalog No. T12821Cas No. 2328109-05-1

S1PR1 modulator 1 is a selective inhibitor of S1PR1, with a pIC50 of 7.6.

Pack Size	Price	Availability
1 mg	$52	In Stock
5 mg	$119	In Stock
10 mg	$173	In Stock
25 mg	$285	In Stock
50 mg	$422	In Stock
1 mL x 10 mM (in DMSO)	$138	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.69%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	S1PR1 modulator 1 is a selective inhibitor of S1PR1, with a pIC50 of 7.6.
Targets&IC50	S1P1 receptor:7.6(pIC50) , S1P3 receptor:6(pIC50)
In vitro	S1PR1 modulator 1 shows >40- and >80-fold selectivity, over the other S1PR isoforms S1PR3 (pIC50, 6), S1PR2 and S1PR4 (pIC50s, <5)[1].

Chemical Properties

Molecular Weight	408.51
Formula	C₂₃H₂₄N₂O₃S
Cas No.	2328109-05-1
Smiles	N(\CCC)=C\1/N(C(=O)\C(=C\C2=CC(C)=C(OC(C)=O)C=C2)\S1)C3=C(C)C=CC=C3
Relative Density.	1.18 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41.26 mg/mL (101 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4479 mL	12.2396 mL	24.4792 mL	122.3960 mL
5 mM	0.4896 mL	2.4479 mL	4.8958 mL	24.4792 mL
10 mM	0.2448 mL	1.2240 mL	2.4479 mL	12.2396 mL
20 mM	0.1224 mL	0.6120 mL	1.2240 mL	6.1198 mL
50 mM	0.0490 mL	0.2448 mL	0.4896 mL	2.4479 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2240 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc