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Radicicol

Name: Radicicol
Brand: TargetMol
SKU: T16719
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16719Cas No. 12772-57-5

Alias Monorden

Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel

Radicicol

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Catalog No. T16719Alias MonordenCas No. 12772-57-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$139	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel
Targets&IC50	HSP90:1 μM
In vitro	Radicicol inhibits PDK1 activity with an IC50 value of 230 mM and PDK3 with an IC50 value of 400 μM.[1]
In vivo	Methods: Radicicol (20 mg/kg/60 mg/kg, intraperitoneal injection, 2 doses, 1 h apart) was administered to mice to observe its inhibitory effect on (I/R) injury in mice. Results: Radicicol has a renal protective effect, improves renal ischemia-reperfusion (I/R) injury, and increases renal HSP70 mRNA and protein in mice with renal injury. [4]
Synonyms	Monorden

Chemical Properties

Molecular Weight	364.78
Formula	C₁₈H₁₇ClO₆
Cas No.	12772-57-5
Smiles	C[C@@H]1C[C@@H]2[C@H](O2)/C=C\C=C\C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
Relative Density.	1.364 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (219.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7414 mL	13.7069 mL	27.4138 mL	137.0689 mL
5 mM	0.5483 mL	2.7414 mL	5.4828 mL	27.4138 mL
10 mM	0.2741 mL	1.3707 mL	2.7414 mL	13.7069 mL
20 mM	0.1371 mL	0.6853 mL	1.3707 mL	6.8534 mL
50 mM	0.0548 mL	0.2741 mL	0.5483 mL	2.7414 mL
100 mM	0.0274 mL	0.1371 mL	0.2741 mL	1.3707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc