IL-18R alpha Protein, Human, Recombinant (hFc)

Name: IL-18R alpha Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-05491
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: interleukin 18 receptor 1, IL-1Rrp, IL1RRP, IL18RA, CDw218a, CD218a) Copy Product Info

Synonyms: interleukin 18 receptor 1, IL-1Rrp, IL1RRP, IL18RA, CDw218a, CD218a

Catalog No. TMPY-05491 Copy Product Info

IL-18R alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5 kDa and the accession number is Q13478.

Pack Size	Price	USA Stock	Global Stock
5 µg	$35	-	In Stock
10 µg	$52	-	In Stock
20 µg	$81	-	In Stock
50 µg	$153	-	In Stock
100 µg	$255	-	In Stock
200 µg	$451	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:93.9%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Loaded Biotinylated Recombinant Human IL-18R beta/IL-18RAP Protein, hFc & Avi Tag (Cat#TMPY-06316) on SA Biosensor, can bind Recombinant Human IL-18Rα Protein, hFc Tag (Cat#TMPY-05491) with an affinity constant of 5.89 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).
Description	IL-18R alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5 kDa and the accession number is Q13478.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q13478
Construction	A DNA sequence encoding the human IL18R1 (NP_003846.1) (Met1-Arg329) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Ala 19
Protein Purity	> 90 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	interleukin 18 receptor 1, IL-1Rrp, IL1RRP, IL18RA, CDw218a, CD218a
Research Background	Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

Chemical Properties

Molecular Weight

62.5 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.