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Iodoantipyrine

Name: Iodoantipyrine
Brand: TargetMol
SKU: T24170
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24170Cas No. 129-81-7

Alias Jodantipyrine, Iodophenazone, EINECS 204-966-6, Arthripur

Iodoantipyrine (Arthripur) is a commonly-used indicator and is used to evaluate in rats by measuring torcular venous efflux after systemic injection of the indicator under conditions of normal and high CBF.

Iodoantipyrine

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Purity: 98.93%

Catalog No. T24170Alias Jodantipyrine, Iodophenazone, EINECS 204-966-6, ArthripurCas No. 129-81-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$40	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Iodoantipyrine AI Summary

Iodoantipyrine shows varying effects on cerebral blood flow in different regions of the rat brain under normocapnia and hypercapnia conditions, indicating a modulatory role. This compound exhibits bioactivity by inhibiting human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of approximately 33,498.3 nM and demonstrates the ability to block Ebola virus entry with AC50 values ranging from 8,912.5 nM to 31.62 µM. Additionally, it shows antiviral activity against SARS-CoV-2, with a 9.99% inhibition of induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours and a 0.17% inhibition in VERO-6 cells at the same concentration and exposure. Iodoantipyrine also exhibits 3.61% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. Furthermore, it has shown inhibitory activity against human HDAC6 with a commercial peptide substrate, achieving a 31.11% inhibition rate, although it demonstrated a negative inhibition rate of -10.76% with a custom peptide substrate in the same assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Iodoantipyrine (Arthripur) is a commonly-used indicator and is used to evaluate in rats by measuring torcular venous efflux after systemic injection of the indicator under conditions of normal and high CBF.
Synonyms	Jodantipyrine, Iodophenazone, EINECS 204-966-6, Arthripur

Chemical Properties

Molecular Weight	314.12
Formula	C₁₁H₁₁IN₂O
Cas No.	129-81-7
Smiles	Cc1c(I)c(=O)n(-c2ccccc2)n1C
Relative Density.	1.77g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (175.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1835 mL	15.9175 mL	31.8350 mL	159.1748 mL
5 mM	0.6367 mL	3.1835 mL	6.3670 mL	31.8350 mL
10 mM	0.3183 mL	1.5917 mL	3.1835 mL	15.9175 mL
20 mM	0.1592 mL	0.7959 mL	1.5917 mL	7.9587 mL
50 mM	0.0637 mL	0.3183 mL	0.6367 mL	3.1835 mL
100 mM	0.0318 mL	0.1592 mL	0.3183 mL	1.5917 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc