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STAT3-IN-12
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Catalog No. T62803Cas No. 2980758-31-2
STAT3-IN-12, a potent STAT3 signaling inhibitor, suppresses IL-6-induced JAK/STAT3 pathway activation. This compound inhibits cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest, making it suitable for hepatocellular carcinoma (HCC) and esophageal cancer research.
STAT3-IN-12
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Purity: 99.19%
Catalog No. T62803Cas No. 2980758-31-2
STAT3-IN-12, a potent STAT3 signaling inhibitor, suppresses IL-6-induced JAK/STAT3 pathway activation. This compound inhibits cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest, making it suitable for hepatocellular carcinoma (HCC) and esophageal cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | - | In Stock | |
| 5 mg | $123 | - | In Stock | |
| 10 mg | $189 | - | In Stock | |
| 25 mg | $396 | - | In Stock | |
| 50 mg | $569 | - | In Stock | |
| 100 mg | $745 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $135 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.19%
Appearance:Solid
Color:Brown
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | STAT3-IN-12, a potent STAT3 signaling inhibitor, suppresses IL-6-induced JAK/STAT3 pathway activation. This compound inhibits cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest, making it suitable for hepatocellular carcinoma (HCC) and esophageal cancer research. |
| Targets&IC50 | HepG2 cells:4.32 μM, EC109 cells:3.63 μM |
| In vitro | Methods: HepG2 and EC109 cells were treated with STAT3-IN-12 (0, 1.25, 2.5, 5, 10 μM, 16-72 hours) and subjected to cell viability assays, cell migration assays, and Western blotting. Results: STAT3-IN-12 inhibited the growth of HepG2 and EC109 cells with IC50 values of 4.32 μM and 3.63 μM, respectively. It selectively inhibited STAT3 tyrosine 705 phosphorylation after 16 hours of treatment. [1] |
| In vivo | Methods: STAT3-IN-12 (20, 40 mg/kg intraperitoneal injection, daily for 24 days) was used to treat HepG2 cell xenograft tumor model mice to study its effect on tumor growth in mice. Results: STAT3-IN-12 was able to inhibit tumor growth in mice without affecting the body weight of the mice. [1] |
| Molecular Weight | 454.56 |
| Formula | C28H30N4O2 |
| Cas No. | 2980758-31-2 |
| Smiles | N=1C=2C=C3N=C(C=4C=CC=C(OC)C4)N(C3=CC2N(C1C=5C=CC=C(OC)C5)CCC)CCC |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (175.99 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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