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STAT3-IN-12
🥰Excellent
Catalog No. T62803Cas No. 2980758-31-2
STAT3-IN-12, a potent STAT3 signaling inhibitor, suppresses IL-6-induced JAK/STAT3 pathway activation. This compound inhibits cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest, making it suitable for hepatocellular carcinoma (HCC) and esophageal cancer research.
STAT3-IN-12
🥰Excellent
Purity: 99.19%
Catalog No. T62803Cas No. 2980758-31-2
STAT3-IN-12, a potent STAT3 signaling inhibitor, suppresses IL-6-induced JAK/STAT3 pathway activation. This compound inhibits cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest, making it suitable for hepatocellular carcinoma (HCC) and esophageal cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $123 | In Stock | |
| 10 mg | $198 | In Stock | |
| 25 mg | $455 | In Stock | |
| 50 mg | $787 | In Stock | |
| 100 mg | $1,280 | In Stock | |
| 200 mg | $1,720 | In Stock |
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Purity:99.19%
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Product Introduction
Bioactivity
Chemical Properties
| Description | STAT3-IN-12, a potent STAT3 signaling inhibitor, suppresses IL-6-induced JAK/STAT3 pathway activation. This compound inhibits cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest, making it suitable for hepatocellular carcinoma (HCC) and esophageal cancer research. |
| Targets&IC50 | EC109 cells:3.63 μM, HepG2 cells:4.32 μM |
| In vitro | Methods: HepG2 and EC109 cells were treated with STAT3-IN-12 (0, 1.25, 2.5, 5, 10 μM, 16-72 hours) and subjected to cell viability assays, cell migration assays, and Western blotting. Results: STAT3-IN-12 inhibited the growth of HepG2 and EC109 cells with IC50 values of 4.32 μM and 3.63 μM, respectively. It selectively inhibited STAT3 tyrosine 705 phosphorylation after 16 hours of treatment. [1] |
| In vivo | Methods: STAT3-IN-12 (20, 40 mg/kg intraperitoneal injection, daily for 24 days) was used to treat HepG2 cell xenograft tumor model mice to study its effect on tumor growth in mice. Results: STAT3-IN-12 was able to inhibit tumor growth in mice without affecting the body weight of the mice. [1] |
| Molecular Weight | 454.56 |
| Formula | C28H30N4O2 |
| Cas No. | 2980758-31-2 |
| Smiles | N=1C=2C=C3N=C(C=4C=CC=C(OC)C4)N(C3=CC2N(C1C=5C=CC=C(OC)C5)CCC)CCC |
| Relative Density. | no data available |
| Color | Brown |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (175.99 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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