Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1/HDAC6, with IC50 of 68.90 nM and 510 nM respectively. PARP-1/HDAC-IN-1 has anti-cancer, anti-migration and anti-angiogenesis activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1/HDAC6, with IC50 of 68.90 nM and 510 nM respectively. PARP-1/HDAC-IN-1 has anti-cancer, anti-migration and anti-angiogenesis activities. |
In vitro | PARP-1/HDAC-IN-1 (Compound 1–8-6) demonstrates significant inhibitory effects on a variety of cell lines, including MDA-MB-436, ES-2, DU145, A549, HCC1937, and Capan-1, with IC50 values ranging from 0.35 μM to 5.67 μM [1]. At concentrations between 0.3 to 10 μM, it notably increases the expression of acetylated α-tubulin while exerting minimal influence on the acetylation levels of histones H3 and H4 [1]. |
Molecular Weight | 402.4 |
Formula | C22H18N4O4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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PARP-1/HDAC-IN-1 inhibitor inhibit