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PARP-1/HDAC-IN-1
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Catalog No. T61962Cas No. 3032621-10-3
PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1 and HDAC6, with IC50 values of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 exhibits anti-cancer, anti-migration, and anti-angiogenesis activities.
PARP-1/HDAC-IN-1
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Purity: 95.94%
Catalog No. T61962Cas No. 3032621-10-3
PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1 and HDAC6, with IC50 values of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 exhibits anti-cancer, anti-migration, and anti-angiogenesis activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | 10-14 weeks | |
| 5 mg | $722 | 10-14 weeks | |
| 10 mg | $987 | 10-14 weeks | |
| 25 mg | $1,520 | 10-14 weeks | |
| 50 mg | $1,980 | 10-14 weeks |
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Purity:95.94%
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Product Introduction
Bioactivity
Chemical Properties
| Description | PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1 and HDAC6, with IC50 values of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 exhibits anti-cancer, anti-migration, and anti-angiogenesis activities. |
| Targets&IC50 | HDAC3:7220 nM, HDAC6:510 nM, HDAC2 (human):42130 nM, ARTD1/PARP1:68.90 nM |
| In vitro | PARP-1/HDAC-IN-1 (Compound 1–8-6) significantly inhibits various cell lines, including MDA-MB-436, ES-2, DU145, A549, HCC1937, and Capan-1, with IC50 values from 0.35 μM to 5.67 μM [1]. At 0.3 to 10 μM, it notably increases acetylated α-tubulin expression while minimally impacting histones H3 and H4 acetylation levels [1]. |
| Molecular Weight | 402.4 |
| Formula | C22H18N4O4 |
| Cas No. | 3032621-10-3 |
| Smiles | O=C(N)C1=CC=CC2=CN(N=C21)C3=CC=C(OCC4=CC=C(C=C4)C(=O)NO)C=C3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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