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Harman hydrochloride

Name: Harman hydrochloride
Brand: TargetMol
SKU: T3158L
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3158LCas No. 21655-84-5

Alias Harmane hydrochloride(486-84-0 Free base)

Harman hydrochloride can directly induce CYP1A1 gene expression in an AhR-dependent manner and may represent a novel mechanism by which harman promotes mutagenicity, co-mutagenicity and carcinogenicity.

Harman hydrochloride

🥰Excellent

Purity: 99.35%

Catalog No. T3158LAlias Harmane hydrochloride(486-84-0 Free base)Cas No. 21655-84-5

Pack Size	Price	Availability
10 mg	$36	In Stock
25 mg	$64	In Stock
50 mg	$98	In Stock
100 mg	$139	In Stock
200 mg	$219	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.35%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Harman hydrochloride can directly induce CYP1A1 gene expression in an AhR-dependent manner and may represent a novel mechanism by which harman promotes mutagenicity, co-mutagenicity and carcinogenicity.
Targets&IC50	MAO-B:5 μM, benzodiazepine receptor:7 nM, I1-Imidazoline receptor:30 nM, Loperamide:163 μM, 5-HT:101 μM, nAChR:24 μM, hMAO-A:0.5 μM, Opioid receptor:2.8 μM, α2-adrenergic receptor:18 μM
Synonyms	Harmane hydrochloride(486-84-0 Free base)

Chemical Properties

Molecular Weight	218.68
Formula	C₁₂H₁₁ClN₂
Cas No.	21655-84-5
Smiles	Cc1nccc2c1[nH]c1c2cccc1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (251.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5729 mL	22.8645 mL	45.7289 mL	228.6446 mL
5 mM	0.9146 mL	4.5729 mL	9.1458 mL	45.7289 mL
10 mM	0.4573 mL	2.2864 mL	4.5729 mL	22.8645 mL
20 mM	0.2286 mL	1.1432 mL	2.2864 mL	11.4322 mL
50 mM	0.0915 mL	0.4573 mL	0.9146 mL	4.5729 mL
100 mM	0.0457 mL	0.2286 mL	0.4573 mL	2.2864 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc