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SMCC-DM1 (GMP)
🥰Excellent
Catalog No. T16899-GMPCas No. 1228105-51-8
SMCC-DM1 (GMP) refers to the GMP grade reagents of SMCC-DM1. SMCC-DM1 is a drug-coupler coupler consisting of a potent microtubule disrupter, DM1, and a coupler, SMCC, for the preparation of antibody-drug couplers.
SMCC-DM1 (GMP)
🥰Excellent
Catalog No. T16899-GMPCas No. 1228105-51-8
SMCC-DM1 (GMP) refers to the GMP grade reagents of SMCC-DM1. SMCC-DM1 is a drug-coupler coupler consisting of a potent microtubule disrupter, DM1, and a coupler, SMCC, for the preparation of antibody-drug couplers.
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Product Introduction
Bioactivity
Chemical Properties
| Description | SMCC-DM1 (GMP) refers to the GMP grade reagents of SMCC-DM1. SMCC-DM1 is a drug-coupler coupler consisting of a potent microtubule disrupter, DM1, and a coupler, SMCC, for the preparation of antibody-drug couplers. |
| In vitro | METHODS: The antiproliferative effects of SMCC-DM1, LDs 17 and LDs 18) on two cell lines, HCC-1954 (her2 positive) and MDA-MB-468 (her2 negative), were evaluated using Promega cell titer-glo fluorescence cell viability assay. RESULTS SMCC-DM1 inhibited the proliferation of HCC1954 and MDA-MB-468 cells with IC50 of 17.2 and 49.9 nM.[1] |
| Molecular Weight | 1072.61 |
| Formula | C51H66ClN5O16S |
| Cas No. | 1228105-51-8 |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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