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Ceruletide Ammonium Salt

Catalog No. T14932L1

Synonyms: Caerulein Ammonium Salt, Ceruletide Ammonium Salt（17650-98-5 Free base), FI-6934 Ammonium Salt, Cerulein Ammonium Salt

Ceruletide Ammonium Salt is a decapeptide, originating from the skin of tropical frogs, which is a potent cholecystokinin receptor agonist and a safe and effective cholecystokinin receptor agonist with direct spasmodic effects on the gallbladder muscle and bile ducts. Ceruletide Ammonium Salt has sedative activity and has been used in the study of chronic schizophrenia.Ceruletide Ammonium Salt is a decapeptide, originating from the skin of tropical frogs.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ceruletide Ammonium Salt Chemical Structure

Ceruletide Ammonium Salt, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 89.00
5 mg	In stock	$ 347.00
10 mg	In stock	$ 516.00
25 mg	In stock	$ 825.00
50 mg	In stock	$ 1,090.00
100 mg	In stock	$ 1,480.00
500 mg	In stock	$ 2,930.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 98.47%

Biological Description

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Storage & Solubility Information

Description	Ceruletide Ammonium Salt is a decapeptide, originating from the skin of tropical frogs, which is a potent cholecystokinin receptor agonist and a safe and effective cholecystokinin receptor agonist with direct spasmodic effects on the gallbladder muscle and bile ducts. Ceruletide Ammonium Salt has sedative activity and has been used in the study of chronic schizophrenia.Ceruletide Ammonium Salt is a decapeptide, originating from the skin of tropical frogs.
In vitro	Ceruletide Ammonium Salt shares chemical and biological similarities with the gastrointestinal hormones cholecystokinin (CCK) and gastrin II in humans. Ceruletide Ammonium Salt stimulates gallbladder contraction, pancreatic exocrine secretion, gastric fluid secretion, and motility in the distal duodenum, jejunum, ileum, and colon, while delaying gastric emptying and inhibiting motility in the proximal duodenum[2]. In vitro, Ceruletide Ammonium Salt activates NF-kappaB/Rel at supraphysiological doses rather than at physiological levels. This activation may induce a self-protective genetic program before cell damage occurs, potentially preventing a higher degree of injury to pancreatic acinar cells after excessive stimulation by secretagogues[1].
In vivo	Ceruletide Ammonium Salt can be utilized for animal modeling, specifically in constructing animal models of pancreatitis. Ceruletide Ammonium Salt (0.4-0.5 μg/kg, intravenous injection; 3-4 μg/kg, subcutaneous injection) induces conscious and complete vomiting and defecation in dogs, with full recovery observed 15-30 minutes and 2-4 hours after intravenous administration or subcutaneous injection, respectively. Ceruletide Ammonium Salt (5-15 ng/kg, intravenous) demonstrates a significant spasmogenic effect on the pylorus in rats. Additionally, Ceruletide Ammonium Salt can reduce blood pressure in anesthetized dogs[2]. Ceruletide Ammonium Salt-stimulated serum bile acids (SBA) evasion eliminates exogenous and endogenous influences associated with postprandial (PP) SBA stimulation. The effectiveness of Ceruletide Ammonium Salt-stimulated SBA in dogs with portosystemic shunts (PSS) may be as good as PP SBA stimulation, and it may be more sensitive in detecting hepatic dysfunction in dogs with upper respiratory disease (URD)[3].

Synonyms	Caerulein Ammonium Salt, Ceruletide Ammonium Salt（17650-98-5 Free base), FI-6934 Ammonium Salt, Cerulein Ammonium Salt
Molecular Weight	1370.44
Formula	C58H77N14O21S2

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bridger N, et al. Comparison of postprandial and ceruletide serum bile acid stimulation in dogs. J Vet Intern Med. 2008 Jul-Aug;22(4):873-8. 2. Vincent ME, et al. Pharmacology, clinical uses, and adverse effects of ceruletide, a cholecystokinetic agent. Pharmacotherapy. 1982 Jul-Aug;2(4):223-34. 3. Steinle AU, et al. NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology. 1999 Feb;116(2):420-30.

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Keywords

Ceruletide Ammonium Salt GPCR/G Protein cholecystokinin Caerulein Ammonium Salt Ceruletide Ammonium Salt（17650-98-5 Free base) FI-6934 Ammonium Salt 17650-98-5 Cerulein Ammonium Salt 17650-98-5 Free base inhibitor inhibit

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