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Ethyl gentisate

🥰Excellent
Catalog No. T37115Cas No. 3943-91-7
Alias Ethyl 2,5-dihydroxybenzoate

Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) acts as a dual regulator of cell differentiation, promoting osteoblast differentiation while inhibiting osteoclast differentiation. It enhances osteogenic differentiation and alkaline phosphatase activity in human mesenchymal stem cells (hMSCs), and suppresses RANKL-activated osteoclastogenesis in RAW264.7 cells.

Ethyl gentisate

Ethyl gentisate

🥰Excellent
Purity: 99.55%
Catalog No. T37115Alias Ethyl 2,5-dihydroxybenzoateCas No. 3943-91-7
Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) acts as a dual regulator of cell differentiation, promoting osteoblast differentiation while inhibiting osteoclast differentiation. It enhances osteogenic differentiation and alkaline phosphatase activity in human mesenchymal stem cells (hMSCs), and suppresses RANKL-activated osteoclastogenesis in RAW264.7 cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$29-In Stock
1 mL x 10 mM (in DMSO)$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.55%
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Product Introduction

Bioactivity
Description
Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) acts as a dual regulator of cell differentiation, promoting osteoblast differentiation while inhibiting osteoclast differentiation. It enhances osteogenic differentiation and alkaline phosphatase activity in human mesenchymal stem cells (hMSCs), and suppresses RANKL-activated osteoclastogenesis in RAW264.7 cells.
SynonymsEthyl 2,5-dihydroxybenzoate
Chemical Properties
Molecular Weight182.17
FormulaC9H10O4
Cas No.3943-91-7
SmilesO=C(OCC)C1=CC(O)=CC=C1O
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 30 mg/mL (164.68 mM), Sonication is recommended.
PBS (pH 7.2): 10 mg/mL (54.89 mM), Sonication is recommended.
DMSO: 80 mg/mL (439.15 mM), Sonication is recommended.
DMF: 30 mg/mL (164.68 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (27.45 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
PBS (pH 7.2)/Ethanol/DMF/DMSO
1mg5mg10mg50mg
1 mM5.4894 mL27.4469 mL54.8938 mL274.4689 mL
5 mM1.0979 mL5.4894 mL10.9788 mL54.8938 mL
10 mM0.5489 mL2.7447 mL5.4894 mL27.4469 mL
20 mM0.2745 mL1.3723 mL2.7447 mL13.7234 mL
50 mM0.1098 mL0.5489 mL1.0979 mL5.4894 mL
Ethanol/DMF/DMSO
1mg5mg10mg50mg
100 mM0.0549 mL0.2745 mL0.5489 mL2.7447 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ethyl 2,5Dihydroxybenzoateethyl 2,5 Dihydroxybenzoate
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