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MMAD

Name: MMAD
Brand: TargetMol
SKU: T4677
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4677Cas No. 203849-91-6

Alias Monomethylauristatin D, Monomethyl Dolastatin 10, Demethyldolastatin 10

MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).

MMAD

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Purity: 99.91%

Catalog No. T4677Alias Monomethylauristatin D, Monomethyl Dolastatin 10, Demethyldolastatin 10Cas No. 203849-91-6

MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$133	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$333	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).
In vitro	MMAD (Monomethyl Dolastatin 10) undergoes a stable oxime-ligation to produce several nearly homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of approximately 2.0. These conjugates exhibit favorable pharmacokinetic properties and potent in vitro cytotoxicity against HER2+ cancer cells. Furthermore, ADCs synthesized using site-specific unnatural amino acids display enhanced in vitro cytotoxicity compared to those prepared through cysteine alkylation after native interchain disulfide reduction.
In vivo	The resulting antibody-drug conjugates (ADCs) demonstrated complete tumor regression in rodents and showed an improved toxicology profile in rats.
Synonyms	Monomethylauristatin D, Monomethyl Dolastatin 10, Demethyldolastatin 10

Chemical Properties

Molecular Weight	771.06
Formula	C₄₁H₆₆N₆O₆S
Cas No.	203849-91-6
Smiles	[H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1
Relative Density.	1.119 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24.5 mg/mL (31.77 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2969 mL	6.4846 mL	12.9692 mL	64.8458 mL
5 mM	0.2594 mL	1.2969 mL	2.5938 mL	12.9692 mL
10 mM	0.1297 mL	0.6485 mL	1.2969 mL	6.4846 mL
20 mM	0.0648 mL	0.3242 mL	0.6485 mL	3.2423 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc