Erlotinib-13C6

Name: Erlotinib-13C6
Brand: TargetMol
SKU: T35915
Rating: 4.5 (1 reviews)

(Synonyms: Erlotinib-13C6) Copy Product Info

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Synonyms: Erlotinib-13C6

Catalog No. T35915 Copy Product Info

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Erlotinib-13C6 is a 13C-labeled Erlotinib. Erlotinib (T0373) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].

Cas No. 1211107-68-4

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$1,988	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Erlotinib-13C6 is a 13C-labeled Erlotinib. Erlotinib (T0373) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].
In vitro	Erlotinib effectively diminishes EGFR autophosphorylation in intact tumor cells, presenting an IC50 value of 20 nM, and is employed in treating non-small cell lung cancer[1]. Additionally, stable heavy isotopes of hydrogen, carbon, and other elements are integrated into drug molecules, primarily serving as tracers for quantification throughout drug development[2].
Synonyms	Erlotinib-13C6

Chemical Properties

Molecular Weight	399.397
Formula	C₂₂H₂₃N₃O₄
Cas No.	1211107-68-4
Smiles	COCCOc1cc2ncnc(N[13c]3[13cH][13cH][13cH][13c]([13cH]3)C#C)c2cc1OCCOC

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc