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AEG 3482

🥰Excellent
Catalog No. T21852Cas No. 63735-71-7

AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.

AEG 3482

AEG 3482

🥰Excellent
Purity: 99.76%
Catalog No. T21852Cas No. 63735-71-7
AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.
Pack SizePriceAvailabilityQuantity
2 mg$29In Stock
5 mg$48In Stock
10 mg$77In Stock
25 mg$173In Stock
50 mg$273In Stock
100 mg$394In Stock
200 mg$573In Stock
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Purity:99.76%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.
In vitro
AEG 3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ∼20 μM. AEG 3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells. AEG 3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner[1].
Chemical Properties
Molecular Weight280.33
FormulaC10H8N4O2S2
Cas No.63735-71-7
SmilesNS(=O)(=O)c1nn2cc(nc2s1)-c1ccccc1
Relative Density.1.75 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (713.4 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5672 mL17.8361 mL35.6722 mL178.3612 mL
5 mM0.7134 mL3.5672 mL7.1344 mL35.6722 mL
10 mM0.3567 mL1.7836 mL3.5672 mL17.8361 mL
20 mM0.1784 mL0.8918 mL1.7836 mL8.9181 mL
50 mM0.0713 mL0.3567 mL0.7134 mL3.5672 mL
100 mM0.0357 mL0.1784 mL0.3567 mL1.7836 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

ApoptosisAEG-3482AEG3482AEG 3482
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